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Unilamellar lipid vesicles have been used as a carrier vehicle to enhance the uptake of actinomycin D into an actinomycin D-resistant Chinese hamster tumor cell line (DC-3F/ADX). The DC-3F/ADX cell line is resistant to actinomycin D as a result of its decreased capacity to transport actinomycin D across the plasma membrane and is able to grow in the(More)
A non-penetrating reagent 4,4'-diisothiocyano-2,2'-ditritiostilbene disulfonic acid ([3H]DIDS) has been used to label isolated normal and diseased myelin. The basic protein and the hydrophobic protein, N-2, were isolated from each myelin. When normal myelin was labeled the specific activity of the basic protein was about 25% of that of the hydrophobic(More)
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