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OBJECTIVE To test the theory of a U-shaped association between time from the first presentation of symptoms in primary care to the diagnosis (the diagnostic interval) and mortality after diagnosis of colorectal cancer (CRC). STUDY DESIGN AND SETTING Three population-based studies in Denmark and the United Kingdom using data from general practitioner's(More)
OBJECTIVE To measure the risk of colorectal cancer and adenoma with new onset rectal bleeding reported to primary care. DESIGN Cohort study. SETTING A rural general practice in the United Kingdom. PARTICIPANTS Patients aged 45 or more with new onset rectal bleeding, irrespective of other symptoms. MAIN OUTCOME MEASURES Percentage of participants in(More)
BACKGROUND Guidelines describing symptoms in children that should alert GPs to consider cancer have been developed, but without any supporting primary-care research. AIM To identify symptoms and signs in primary care that strongly increase the likelihood of childhood cancer, to assist GPs in selection of children for investigation. DESIGN AND SETTING A(More)
OBJECTIVES To evaluate the risk of aortic aneurysm in patients with giant cell arteritis (GCA) compared with age-, gender- and location-matched controls. METHODS A UK General Practice Research Database (GPRD) parallel cohort study of 6999 patients with GCA and 41 994 controls, matched on location, age and gender, was carried out. A competing risk model(More)
BACKGROUND The risk of cancer with hypercalcaemia in primary care is unknown. METHODS This was a cohort study using calcium results in patients aged ⩾40 years in a primary care electronic data set. Diagnoses of cancer in the following year were identified. RESULTS Participants (54 267) had calcium results: 1674 (3%) were ⩾2.6 mmol l(-1). Hypercalcaemia(More)