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OBJECTIVE To test the theory of a U-shaped association between time from the first presentation of symptoms in primary care to the diagnosis (the diagnostic interval) and mortality after diagnosis of colorectal cancer (CRC). STUDY DESIGN AND SETTING Three population-based studies in Denmark and the United Kingdom using data from general practitioner's(More)
Almost all commentators accept that the United Kingdom poor performance in cancer is genuine. (Coleman et al, 2011) Of more interest is why this should be so; in particular, how much of the problem rests in diagnostic delay? The evidence for diagnostic delay includes poor 1-year mortality (Morris et al, 2011), a high number of general practice consultations(More)
T he administration of succinylcholine (SCh) in humans results in a mild and transient hyperkalemia. In normal individuals, the increase in serum potassium (K) is approximately 0.5–1.0 mEq/L, occurs within 3–5 minutes after the IV administration of SCh, and lasts ,10–15 minutes (1). This increase is probably caused by K release from cells as a result of(More)
Ever since Sorsby described his pseudoinflammatory dystrophy in five families, its characteristics have been unclear. The findings in ten affected members of a seven-generation pedigree are discussed and the literature is reviewed. Patients with this dominantly inherited fundus dystrophy lose central vision between the second and fourth decade of life.(More)
BACKGROUND There is controversy as to the efficacy of various measures in the prophylaxis of endophthalmitis after cataract surgery. In addition, it has been suggested that clear-corneal incisions may convey an increased risk of postoperative infection. We performed a retrospective review to assess the effect of prophylactic antibiotics and incision type on(More)
OBJECTIVE To measure the risk of colorectal cancer and adenoma with new onset rectal bleeding reported to primary care. DESIGN Cohort study. SETTING A rural general practice in the United Kingdom. PARTICIPANTS Patients aged 45 or more with new onset rectal bleeding, irrespective of other symptoms. MAIN OUTCOME MEASURES Percentage of participants in(More)
BACKGROUND Individuals with undiagnosed lung and colorectal cancers present with non-specific symptoms in primary care more often than matched controls. Increased access to diagnostic services for patients with symptoms generates more early-stage diagnoses, but the mechanisms for this are only partially understood. METHODS We re-analysed a UK-based(More)
To examine whether the hemodynamic responses to halothane or morphine-nitrous oxide anesthesia produce different patterns of myocardial ischemia in patients undergoing myocardial revascularization, we studied 26 patients anesthetized with nitrous oxide (50%) and either halothane (0.2% to 1.0% end-tidal concentration) or morphine (2 mg/kg, given(More)