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The whole-body inflammatory response produced by cardiopulmonary bypass is an important cause of perioperative morbidity after cardiac operations. This inflammatory response produces reactive oxygen species and other cytotoxic substances, such as the cytokines. The generation of reactive oxygen species might deplete principal antioxidant micronutrients,(More)
The mechanical behavior of human liver has been characterized with aspiration experiments. Measurements have been performed in vivo under sterile conditions during open surgery. Twenty-three measurements on six healthy human livers were performed using the same loading history for each test, so to allow a direct comparison of the measured deformations. The(More)
Immediate hypersensitivity reactions to parenteral glucocorticoids are rare but often serious and life-threatening. In the medical literature some hundred case reports of corticoid hypersensitivity after parenteral administration have been published. The pathomechanism may be immunological or non-immunological in nature and the reaction can be due to the(More)
OBJECTIVES The aim of this study was to evaluate the effects of high intensity exercise training on left ventricular function and hemodynamic responses to exercise in patients with reduced ventricular function. BACKGROUND Results of studies on central hemodynamic adaptations to exercise training in patients with chronic heart failure have been(More)
Interrupted aortic arch, defined as complete luminal and anatomic discontinuity between ascending and descending aorta, is an uncommon and highly lethal anomaly. We report the case of a 72-year-old woman scheduled for aortic valve replacement because of severe regurgitation. During preoperative catheterization, it was not possible to reach the ascending(More)
Exercise training has recently become an accepted therapeutic modality in chronic heart failure after myocardial infarction. Because the therapeutic mechanism behind it is controversial and not well understood, we analyzed the influence of exercise training on blood viscosity. Twenty-five patients with chronic heart failure (ejection fraction < 40%) after(More)
BACKGROUND Endothelin-1 is involved in chronic pulmonary hypertension. Its role in acute pulmonary hypertension due to hypoxia in humans is not clear. We therefore studied the influence of hypoxia caused by exposure to high altitude on plasma endothelin-1 levels, arterial blood gases, and pulmonary arterial pressure in subjects taking nifedipine or placebo.(More)
PURPOSE Red blood cells (RBCs) express N-methyl D-aspartate (NMDA) receptors on their surface. We tested if NMDA receptor activation or inhibition had an influence on RBC deformability and aggregability. METHODS Heparinized blood was drawn from healthy volunteers and centrifuged. RBCs were washed twice and resuspended with a hematocrit of 30% in a same(More)
BACKGROUND Elevated blood glucose levels are associated with substantial morbidity and mortality. The pathomechanism behind it is not well understood. The aim of the present study was to investigate the effect of glucose on blood rheology. MATERIALS AND METHODS Blood from healthy volunteers was incubated with various concentrations of D- and L-glucose for(More)