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The intravenous administration of superoxide dismutase (superoxide:superoxide oxidoreductase, EC to animals with induced inflammation suppresses the inflammatory response and inhibits leukocyte infiltration into the challenged site, suggesting that neutrophil-generated superoxide reacts with an extracellular precursor to generate a substance(More)
Several models of inflammation induced in laboratory animals were markedly inhibited by intravenous administration of the enzyme superoxide dismutase. In most cases, the enzyme required chemical modification to increase its circulating lifetime. In all cases, histological examination of the sites of the potential lesions revealed that treatment with(More)
The inhalation of SO2 or the ingestion of beverages or food containing sulfite as a preservative has been associated with exacerbations of obstructive pulmonary disease. In this study it is demonstrated that 15-HPETE, a likely component of the lung's inflammatory response, can initiate the autoxidation of sulfite. Since 1 mol of 15-HPETE can initiate the(More)
The NADPH oxidase of human neutrophils is highly sensitive to calcium concentration and is inhibited in intact cells and cell-free preparations by various phenothiazine drugs. Addition of calmodulin to preparations of NADPH oxidase stimulates enzymatic rates from 1.4-2.5-fold. Addition of calmodulin and calcium, but not calcium alone, to NADPH oxidase(More)
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