W F Bosron

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Since alcohol dehydrogenase (ADH) catalyzes the rate-limiting step for ethanol metabolism, knowledge of the steady-state kinetics of ADH in liver is fundamental to the understanding of the pharmacokinetics of ethanol elimination. Accordingly, we have determined the kinetic properties of purified ADH isoenzymes in rat and human liver. At low ethanol(More)
The stimulant effects of cocaine are relatively short lived, as evidenced by the increase in heart rate that peaks at about 60 minutes after cocaine administration and declines thereafter (Farre et al. 1993). This duration of effect is largely due to the rapid hydrolysis of cocaine to two major deesterified metabolites that appear in serum and urine,(More)
Abuse of cocaine in combination with other drugs is a widespread practice (Washton and Gold 1987) and the coabuse of alcohol is particularly common, with 99 percent of cocaine addicts reporting excessive use of ethanol in one study (Newcombe and Bentler 1987). Simultaneous ingestion of ethanol also is common, as reported by 77 percent of cocaine users(More)
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