W. D. Lotspeich

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Transformation of the slightly alkaline glomerular filtrate into acid urine has been assigned in man (1 ) as in the dog (2) to the exchange of hydrogen ions formed within the tubular cells for ions of fixed base in the tubular urine. The most acid urine which the kidney can form is of pH 4.5 to 4.7 (1, 3). At this reaction negligible quantities of strong(More)
Inorganic sulfate is formed during the metabolism of the sulfur-containing amino acids. Although its exact functions are not well understood, the body nevertheless maintains a basic store of circulating sulfate at all times. Its plasma level, although low, is fairly constant, being maintained in the normal dog within limits of 1.2 and 1.8 millimols per(More)
The state of metabolic acidosis involves changes of a varied and subtle nature in other organs as well as in the kidney. This fact has been illustrated in metabolic studies with glutamine, a major substrate of the kidney and of various other organs. In addition to the well-described increase in renal glutaminase enzymes, the hexose monophosphate-shunt(More)
LOTSPEICH, WILLIAM D. Renal hypertrophy in metabolic acidosis and its relation to ammonia excretion. Am. J. Physiol. 208(6) : I 135-1142. 1 g65.-The chronic ingestion of NH&l causes a true growth of the rat kidney. This involves a symmetrical increase in wet weight, dry weight, and nitrogen of the kidney tissue. Total DNA and RNA are also elevated,(More)