W. D. Fraser

A. Sayers2
J. A. Carron2
D. A. Lawlor2
J. H. Tobias2
J. A. Gallagher2
2A. Sayers
2J. A. Carron
2D. A. Lawlor
2J. H. Tobias
2J. A. Gallagher
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Abnormalities of bone metabolism and increased vascular calcification are common in chronic kidney disease (CKD) and important causes of morbidity and mortality. The Wnt signaling pathway may play a role in the bone and vascular disturbances seen in CKD, termed collectively “CKD–MBD.” The aim of the study was to investigate the possible association of(More)
Previous reports have shown the production of parathyroid hormone-related protein (PTHrP) by breast cancer cells in vivo and in vitro. We have investigated the expression of the PTH/PTHrP receptor by the human breast cancer cell lines MCF-7, ZR-75-1, T-47-D, SK-BR-3, Hs578T and MDA-MB231. Using reverse transcription-polymerase chain reaction (RT-PCR) and(More)
CONTEXT Intracellular fat within muscle and visceral tissue has been suggested to adversely influence bone development. OBJECTIVE The aim of the study was to evaluate associations between im fat, as reflected by muscle density as measured by peripheral quantitative computed tomography, and cortical bone parameters in young adults. (More)
Using RNA extracted from human tumour samples removed during surgery, we have analysed expression of mRNA for parathyroid hormone-related protein (PTHrP) and for the PTH/PTHrP receptor by RT-PCR in a panel of human breast and colon tumours. All but 1 of 18 breast tumour samples expressed PTHrP, whereas receptor expression was detected in 11 of these.(More)
UNLABELLED In exploring relationships between vitamin D status in childhood and cortical bone, little relationship was observed with plasma concentrations of 25-hydroxyvitamin-D(2) [25(OH)D(2)], whereas 25-hydroxyvitamin-D(3) [25(OH)D(3)] was positively related to cortical bone mineral content (BMC(C)) and cortical thickness, suggesting D(3) exerts a(More)
Positive pressure breathing (PPB) is a survival system that delivers high-pressure oxygen and body counterpressure in the event of cockpit depressurization at high altitude, but the ability of aircrew to perform an emergency "get-me-down" maneuver with this system is unknown. To address this question, a serial choice reaction time (RT) task was administered(More)
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