W.D. Foulkes

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Three loci have been implicated in familial Wilms tumour: WT1 located on chromosome 11p13, FWT1 on 17q12-q21, and FWT2 on 19q13. Two out of 19 Wilms tumour families evaluated showed strong evidence against linkage at all three loci. Both of these families contained at least three cases of Wilms tumour indicating that they were highly likely to be due to(More)
There is increasing evidence that predisposition to some cancers has a genetic component. There is a high incidence of loss of heterozygosity on chromosome 9, in the region of tumour suppressor gene, CDKN2A (also known as p16), in sporadic squamous cell cancer of the head and neck (SCCHN). To investigate the possibility that CDKN2A may be involved in the(More)
cell carcinoma of the head and neck (SCCHN) is the sixth commonest human malignancy with an estimate of nearly 900 000 new cases occurring worldwide in 1995 (Parkin et al, 1993). In this review, head and neck cancer is defined as squamous cell carcinoma occurring in the upper aerodigestive tract, superior to the clavicles, excluding skin cancer and(More)
The opinions expressed in the abstracts are those of the authors and are not to be construed as the opinion of the publisher (Multimed Inc.), the organizers of the Third International Symposium on Hereditary Breast and Ovarian Cancer, or the Hereditary Breast and Ovarian Cancer Foundation. Although the publisher (Multimed Inc.) has made every effort to(More)
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