W. Brent Lindquist

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The classic 'size principle' of motor control describes how increasingly forceful movements arise by the recruitment of motoneurons of progressively larger size and force output into the active pool. We explored the activity of pools of spinal interneurons in larval zebrafish and found that increases in swimming speed were not associated with the simple(More)
The structure of neuronal dendrites and their spines underlie the connectivity of neural networks. Dendrites, spines, and their dynamics are shaped by genetic programs as well as sensory experience. Dendritic structures and dynamics may therefore be important predictors of the function of neural networks. Based on new imaging approaches and increases in the(More)
ÐWe consider the problem of segmenting a digitized image consisting of two univariate populations. Assume a priori knowledge allows incomplete assignment of voxels in the image, in the sense that a fraction of the voxels can be identified as belonging to population 0, a second fraction to 1, and the remaining fraction have no a priori identification. Based(More)
We describe the synthesis of automated neuron branching morphology and spine detection algorithms to provide multiscale three-dimensional morphological analysis of neurons. The resulting software is applied to the analysis of a high-resolution (0.098 microm x 0.098 microm x 0.081 microm) image of an entire pyramidal neuron from layer III of the superior(More)
In rat barrel cortex, development of layer 2/3 receptive fields can be disrupted by sensory deprivation, with a critical period ending around postnatal day (PND) 14. To determine if experience-dependent plasticity of dendritic morphology could contribute to the reorganization of synaptic inputs, we analyzed dendritic structure in acute brain slices using(More)
We introduce the medial axis as a tool in the analysis of geometric structure of void space in porous media. The medial axis traces the fundamental geometry of the void pathways. We describe an algorithm for generating the medial axis of the void structure from digitized three dimensional images of porous media obtained from X ray CAT scans. The medial axis(More)
We introducethe medial axis transformas a tool in the analysis of geometricstructure of void space in porous media. The technique is used to study high (5 micron) resolution, three dimensional , synchrotron computed microtomographic data consisting of two drill core samples (Berea sandstone and Danish chalk) and a sample of uniform diameter, packed glass(More)
We show that arc menisci configuration under primary drainage in capillary tube cross sections and, by extension, in throats in the void structure of rock and soil, can be understood in terms of the computational geometry theory of medial axis analysis. The solution for arc meniscus configuration is developed for cross sections of arbitrary, simply(More)
The standard approach in accounting for hierarchical differentiation in biology and the social sciences considers a hierarchy as a static distribution of individuals possessing differing amounts of some valued commodity, assumes that the hierarchy is generated by micro-level processes involving individuals, and attempts to reverse engineer the processes(More)