W. Blondel

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This study aims at investigating the efficiency of bimodal spectroscopy in detection of hypertrophic scar tissue on a preclinical model. Fluorescence and Diffuse Reflectance spectra were collected from 55 scars deliberately created on ears of 20 rabbits, amongst which some received tacrolimus injection to provide non-hypertrophic scar tissue. The(More)
Combining autofluorescence (AF) and Diffuse Reflectance (DR) spectroscopies is supposed to improve diagnosispsila accuracy of early stages of cancer (as well as precancerous stages) which is of great clinical importance. For the present study, we developed a bimodal instrumentation combining spatially resolved AF and DR spectroscopies, and evaluated its(More)
For the estimation of in vivo tissue optical parameters based on spatially-resolved diffuse reflectance spectroscopy measures, a non-derivative Particle Swarm Optimisation approach was successfully applied as part of the inverse problem solving associated to forward Monte Carlo simulations to avoid trapping in local minima.
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