Learn More
BACKGROUND Digital image analysis was found to be a useful technique for improved accuracy of preoperative diagnosis of melanocytic lesions. In previous studies digitized color slides were used as input for digital image analysis. New technologies and smaller video cameras made it possible to develop a camera system that allows the digitization of skin(More)
Bayesian belief networks (BBNs) are a novel tool for representing knowledge about diagnostic decision making and for obtaining a numerical measure of certainty in the final diagnosis. Belief networks have been applied to the pathological assessment of breast, prostate and skin lesions and have been shown to provide consistency in the grading of microscopic(More)
The nuclear morphology of preneoplastic and unaltered hepatocytes in diethylnitrosamine-treated rats was investigated. Two-micrometer-thick sections of methacrylate-embedded liver were scanned with a TV camera and evaluated in a computer using multivariate analysis methods. The preneoplastic cell populations (islands) were distinguished from unaltered(More)
Images of exponentially growing mouse L fibroblasts were used to test whether G1, S, and G2 cells could be discriminated by means of densitometric, geometric, textural and chromatin features. The cells were preincubated with FUdR and labeled with 3H-TdR. The definition of G1, S, and G2 was based on autoradiography used to define labeled S cells, and DNA(More)
Cells of a benign pigmented mole and a malignant melanoma were used to compare electron microscopy (EM) and light microscopy (LM) with high-resolution TV-scanning and multivariate analysis methods. Special emphasis was placed on different kinds of chromatin texture features and their discriminating power. Comparative studies on EM and LM are useful to look(More)
The incidence of malignant melanoma, the most dangerous skin cancer, has increased rapidly during the last decade, and the figures are still rising. Since well-trained and experienced dermatologists are able to reach only a diagnostic accuracy of about 75% in visual preoperative classification, the discriminating ability of digital image analysis was(More)
BACKGROUND Photographic documentation of melanocytic skin lesions is important. Storage and retrieval of slides, however, take much time and space. OBJECTIVE Our purpose was to develop and clinically test a computerized acquisition and surveillance (CAS) unit with a television camera for monitoring including measurements of lesional areas. METHODS A CAS(More)
The malignant melanoma (MM) is the most dangerous human skin disease. The incidence increased dramatically during the last years. The only chance for the patient is an early recognition and excision of the MM. The best diagnostic method for this is skin surface microscopy or dermatoscopy. Its use, however, requires much expertise. In order to support(More)