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It has recently been demonstrated that selective inhibition of both neuronal constitutive and inducible nitric oxide synthases (ncNOS and iNOS) is neuroprotective in a model of dynorphin (Dyn) A(1-17)-induced spinal cord injury. In the present study, various methods including the conversion of 3H-L-arginine to 3H-citrulline, immunohistochemistry and in situ(More)
OBJECTIVE To study the diagnosis and treatment of adrenal cortical carcinoma. METHODS Fifteen cases of adrenal cortical carcinoma (8 functional and 7 nonfunctional) were treated surgically during the period of 1978 - 1998. They were confirmed operatively and pathologically. RESULTS The functional carcinoma usually showed typical clinical features such(More)
The pharmacological effects of nitric oxide synthase (NOS) inhibitors, NO donor, and NOS substrate on dynorphin(Dyn) A(1-17) spinal neurotoxicity were studied. Intrathecal (i.t.) pretreatment with both 7-nitroindazole 1 micromol, a selective neuronal constitutive NOS (ncNOS) inhibitor, and aminoguanidine 1 micromol, a selective inducible NOS (iNOS)(More)
OBJECTIVE To establish a method for measuring the constitutive and inducible nitric oxide synthase (NOS) through the conversion of L-3H arginine to L-3H citrulline. METHODS NOS extracted from cerebellar of porcine and rat was purificated through DEAE cellulose or/and 2', 5', -ADP agarose. NOS activity was assayed by monitoring the conversion of(More)
OBJECTIVE To observe the role of NMDA receptor-Nitric Oxide(NOS)-cGMP pathway in ischemic brain injury. METHODS The common cervical arteries of the rats were transient blocked bilaterally, in association with bleeding from their tails and followed by reperfusion. The procedures were repeated once again as above to establish a stable ischemic brain injury(More)
The effect of tetramethylpyrazine (TMP) on lymphocytes proliferation response (LPR) detected by 3H-TdR incorporation into murine monocytes. The results showed that TTMP at the concentration of 100-1000 micrograms/ml inhibited LPR in normal mice and B14-melanoma bearing mice in vitro the effect was dose-dependent. It was also found TTMP could stimulate LPR(More)
It has been shown that the novel immunopotentiator Polyactin A (PAA) developed in China can augment NK cell activity. In order to further understand the mechanism of PAA effect on NK activities, we measured the binding and lytic capacities of peripheral blood lymphocytes (PBL) isolated from normal subjects and patients with esophageal carcinoma against K562(More)
OBJECTIVE To elucidate the effects of N-methyl-D-aspartate(NMDA) receptor and nitric oxide synthase (NOS) activity in dynorphin (Dyn)-induced spinal cord injury. METHODS The NMDA receptor activity was measured by radio-ligand of 3H-MK801. The constitutive and inducible NOS (cNOS and iNOS) activities were assayed by 3H-arginine conversion. RESULTS In(More)