W A Long

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The effect of chronic maternal hypoxia on substance-P immunoreactivity (SPI) was examined in brainstem regions of fetal (gestational day E-28), neonatal (postnatal days 3, 7, 14, 21), and adult rabbits. Time-dated pregnant rabbit does were housed in environmental chambers at gestational day E-10. Between E-14 and E-28, the pregnant does were separated into(More)
During exposure to hypoxia newborns hypoventilate following a brief period of hyperventilation. Failure of integration of the afferent signals from peripheral O2 chemoreceptors due to immaturity of the central respiratory centers could explain this paradoxical respiratory response. To test this hypothesis we have utilized anesthetized, paralyzed,(More)
We examined the effect of chronic maternal hypoxia on methionine-enkephalin concentrations in fetal (gestational day E-28) and neonatal (postnatal days 3, 7, 21) brainstem regions. Pregnant rabbits were housed in environmental chambers at gestational day E-10. Between E-14 and E-28 the pregnant rabbits were separated into two groups. Group I were controls(More)
Recent work from this laboratory (J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 55:483-488, 1983) has shown that the biphasic respiratory response to hypoxia in piglets is due to changing central neural respiratory output. To test the hypothesis that either adenosine or opiatelike neurotransmitters mediate the failure to sustain hyperpnea in(More)
Afferent inputs to the central neuronal networks responsible for respiratory control can have effects on respiratory output that persist even after cessation of the original stimulus. In adults, carotid sinus nerve (CSN) stimulation activates a central excitatory mechanism which causes prolonged elevation of respiratory output. In newborns, superior(More)
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