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Moulds of the genus Alternaria are common contaminants of some food crops. Some isolates have been shown to produce mutagenic compounds called altertoxins. Altertoxin I (ATX-I) and altertoxin III (ATX-III) were examined for activity in the Raji cell Epstein-Barr virus early antigen (EBV-EA) induction system and in the C3H/10T1 2 murine fibroblast cell(More)
5-(3, 3-Dimethyl-l-triazeno) imidazole-4-carboxamide (DIC) is a well known anti-tumour agent undergoing clinical trial. It has the disadvantage of being very photo-sensitive. The related aryltriazenes, however , do not decompose in this fashion although they are acid labile, to an extent dependent on the ring substituents. In the case of 1-aryl-3,(More)
Agmatine is an endogenous brain metabolite, decarboxylated arginine, which has neuroprotective properties when injected intraperitoneally (i.p.) into rat pups following hypoxic-ischemia. A previous screen for compounds based on rat brain lysates containing agmatinase with assistance from computational chemistry, led to piperazine-1-carboxamidine as a(More)
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