A version of the toll setting problem consists in determining profit maximizing tolls on a subset of arcs of a transportation network, given that users travel on shortest paths. This yields a bilevel program for which we propose efficient algorithms based on path generation.
Regenerative events for different queueing models are considered. The aim of this paper is to construct these events for continuous-time processes if they are given for the corresponding discrete-time model. The construction uses so-called renovative events revealing the property of the state at time n of the discrete-time model to be independent (in an… (More)
Possibility of ortho-, para-, meta-methylphenyl and methoxyphenyl-derivates of MPTP to produce parkinsonism was investigated. Only ortho-methylphenyl- and ortho-methoxyphenyl-derivates of MPTP cause a persistent loss in dopamine content in the brain and produced the clinical symptoms of parkinsonism. All substances produced Parkinsonian-like syndrome gives… (More)
Embryonic prealbumin (E.P.A.) was demonstrated by agar immunodiffusion in 122 out of 505 homogenates of various tumours and in 7 out of 20 serum samples from patients with connective-tissue tumours. Analogous antigen was found in human embryonic and adult cultured fibroblasts. This newly identified antigen is probably actively secreted by fibroblasts into… (More)