The KDM4 histone demethylases are conserved epigenetic regulators linked to development, spermatogenesis and tumorigenesis. However, how the KDM4 family targets specific chromatin regions is largely unknown. Here, an extensive histone peptide microarray analysis uncovers trimethyl-lysine histone-binding preferences among the closely related KDM4 double… (More)
An experimental study of the physical processes in a thin plasma jet produced by the pulsed discharges in the capillary with evaporated wall is described. The losses in mass from capillary wall as well as the transferred charge are accurately measured. The velocity of plasma jet propagation is measured, too. The current structure in plasma is studied. It is… (More)
Vestibular dysfunction was studied in 95 patients with initial cerebral circulatory insufficiency (CCI) stage I and II. Sinusoidal rotation proved highly effective in staging the disease, as initial CCI responses with vestibular hyperreflexia to sinusoidal rotation with closed eyes. With CCI progression, some patients demonstrated inhibition of vestibular… (More)
We have found that two important brain synaptic receptor systems are very sensitive to the influence of low intensity microwaves. Both the excitatory glutamatergic and the inhibitory GABAergic are affected by microwave exposure. Power densities higher 50 microW/cm2 caused changes in the binding properties of these receptors to agonists. Low frequence… (More)
The effect of 800 mHz microwaves of 0, 3, 5, 7, 16, and 30 Hz modulation on GABA receptor concentration in rat brain cortex has been investigated. Irradiation of the whole body at a modulation frequency of 16 Hz readily decreases the GABA receptor concentration. Irradiation at other modulation frequencies is ineffective. Irradiation of the whole body… (More)
A study was made of the effect of gamma-radiation on binding of muscimol, a GABA agonist, by synaptic membranes of rat brain cortex. Exposure to 2 Gy radiation was shown to reduce [3H]-muscimol binding to membranes.
It has been shown that tetrodotoxin inhibits GABA-receptor binding of muscimol with solubilized membranes of the rat brain in a competitive manner, with the inhibition constant amounting to about 3 nM. Muscimol has been also demonstrated to competitively inhibit 3H-tetrodotoxin binding with the same drug.
It was shown that exposure of rats to microwaves (800 MHz, 16 Hz modulation, 1-3 mW/cm2) decreased muscimol binding with synaptic membranes and reduced acetycholinesterase activity in the rat brain.
The effect of methionine-enkephalin (Met-Enk) on responses of rat brain neostriatum neurones to microiontophoretic application of glutamate was studied in experiments with extracellular recording of spike activity. Met-Enk administered by microiontophoresis was shown to depress the glutamate-induced responses. In parallel experiments with synaptic membranes… (More)