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Birth of Industry 5.0: Making Sense of Big Data with Artificial Intelligence, "The Internet of Things" and Next-Generation Technology Policy.
TLDR
We propose Industry 5.0 that can democratize knowledge coproduction from Big Data with safety, innovative technology policy, and responsible implementation science, enabled by 3D symmetry in innovation ecosystem design. Expand
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CYP1A2 Activity as Measured by a Caffeine Test Predicts Clozapine and Active Metabolite Norclozapine Steady-State Concentration in Patients With Schizophrenia
Clozapine is an atypical antipsychotic drug and displays efficacy in 30% to 60% of patients with schizophrenia who do not respond to traditional antipsychotics. A clozapine concentration greater thanExpand
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Treatment-Resistance to Clozapine in Association With Ultrarapid CYP1A2 Activity and the C → A Polymorphism in Intron 1 of the CYP1A2 Gene: Effect of Grapefruit Juice and Low-Dose Fluvoxamine
Antipsychotic response to clozapine varies markedly among patients with schizophrenia. The disposition of clozapine is dependent, in part, on the cytochrome P-450 (CYP) 1A2 enzyme in vivo. In theory,Expand
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Designing a post-genomics knowledge ecosystem to translate pharmacogenomics into public health action
Translation of pharmacogenomics to public health action is at the epicenter of the life sciences agenda. Post-genomics knowledge is simultaneously co-produced at multiple scales and locales byExpand
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Pharmacogenetics of antipsychotic treatment: lessons learned from clozapine
The reintroduction of clozapine, the prototype of atypical antipsychotics, in the late 1980s has led to significant advances in the pharmacological management of schizophrenia. Since then, there hasExpand
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Psychiatric pharmacogenetics: personalizing psychostimulant therapy in attention-deficit/hyperactivity disorder
There is a substantial amount of variation in response and adverse drug reactions to psychostimulant therapy in attention-deficit/hyperactivity disorder (ADHD). Psychiatric pharmacogenetics is aExpand
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Ready to put metadata on the post-2015 development agenda? Linking data publications to responsible innovation and science diplomacy.
Metadata refer to descriptions about data or as some put it, "data about data." Metadata capture what happens on the backstage of science, on the trajectory from study conception, design, funding,Expand
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‘Regular science’ is inherently political
With allusions to Nietzsche, violent anti‐GM organisms groups, nefarious ‘parallel scientists’ and numerous other actors and actions, Marcel Kuntz manufactures a bizarre alchemy to cast postmodernismExpand
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A Systems Biology Approach to Reveal Putative Host-Derived Biomarkers of Periodontitis by Network Topology Characterization of MMP-REDOX/NO and Apoptosis Integrated Pathways
Periodontitis, a formidable global health burden, is a common chronic disease that destroys tooth-supporting tissues. Biomarkers of the early phase of this progressive disease are of utmostExpand
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A comparison of the regulatory frameworks governing microbial testing of drinking water in three Canadian provinces
In Canada, the provinces have primary responsibility for water management, including drinking water management; the federal government has comparatively more limited water-related responsibilities.Expand
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