Vsevelod Belousov

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Phosphorylation of translation initiation factor 2α (eIF2α) attenuates global protein synthesis but enhances translation of activating transcription factor 4 (ATF4) and is a crucial evolutionarily conserved adaptive pathway during cellular stresses. The serine-threonine protein phosphatase 1 (PP1) deactivates this pathway whereas prolonging eIF2α(More)
With all powdered mate r ia l s , an increase in compacting p re s su re leads to an increase in the s trength and density of the tablets. In the f i rs t stage of compacting, a smal l increase in p r e s s u r e resul ts in a cons iderable increase in density. On increas ing the compacting p r e s s u r e , the increase in density result ing f rom the p r(More)
Up until recently, prior moist or dry granulation of the powders was most often used in making tablets of medicinal preparations. Granulation in a fluidized bed is also classified as moist granulation and differs only with respect to combining several technological operations in one installation [17]. Despite all of its apparent advantages, compression(More)
In the compact ing of powdered m a t e r i a l s , a p r e s s u r e which is l e s s than the axial compact ing p r e s s u r e (p) acts on the side walls of the die at the point of fo rmat ion of the tablet . The l a t e ra l p r e s s u r e (Pl) is p a r t of the applied axial p r e s s u r e . Without knowing the value of the l a te ra l p r e s s u r e(More)
However , despi te this , the p rob lem of obtaining a high-qual i ty ins t rument is quite complex technically. And, at the same t ime, not only the qual i ty of the table ts and loss f r o m re jec ted m a t e r i a l , but atso the work of the whole table t machine , depend on the p rec i s ion and c la r i ty of the working e lements of the p r e s s(More)
Powder p a r t i c l e s a re genera l ly dis t r ibuted by size and shape, these being two of the mos t impor tan t c h a r a c t e r i s t i c s which influence the i r physical and technological p r o p e r t i e s (even of one and the same substance). Other impor tan t p a r a m e t e r s a re bulk density, specif ic volume, specific sur face , density,(More)
i. N.N. Chamin, Separation of Proteins as Individual Chemical Compounds by Methods of Controlled Salting Out, Selective Extraction, and Chromatography [in Russian], Candidate's Dissertation, Leningrad (1967). 2. V.V. Naiimov and N. A. Chernova, Statistical Methods of Plannihg Extremal Experiments [in Russian], Moscow (1965). 3. R.I. Karateeva and F. Yu.(More)
The analys is of the s t ee l s used abroad shows that the ma jo r i t y of g rades do not coincide with the s tandard s tee ls of Russ ian production. The a t tempts of a number of f i r m s to c rea te specia l s tee ls mos t fully cor responding to the specif ic f ea tu res of the tablet ing of powders with v e r y different physical p r o p e r t i e s(More)
The se rv i ce life of the p r e s s ins t rument (dies and punches) of r o t a r y table t p r e s s e s does not exceed 3 to 4 months in operat ion with many medic ina l powders , and the re fo re it is n e c e s s a r y to p r e p a r e them in la rge numbe r s in plants of the medica l industry min i s t ry . The g r e a t e r par t of the p r e s s ins(More)