Von Neumann

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DNA and modified vaccinia virus Ankara (MVA) are vaccine vehicles suitable and safe for use in humans. Here, by using a multicytotoxic T-lymphocyte (CTL) epitope gene and a DNA prime-MVA boost vaccination regimen, high levels of CTLs specific for a single simian immunodeficiency virus (SIV) gag-derived epitope were elicited in rhesus macaques. These(More)
Reliable and effective induction of cytotoxic T-lymphocytes (CTL) is one of the prime objectives of vaccine research. Previously, novel HIV vaccine candidates were constructed as a string of CTL epitopes (20 human, 3 macaque and 1 mouse) delivered using a DNA vector [Hanke T, Schneider J, Gilbert SG, Hill AVS, McMichael A. DNA multi-CTL epitope vaccines for(More)
Staphylococcus simulans biovar staphylolyticus secreted two bacteriolytic peptidoglycan hydrolases as proproteins that were activated as they were processed by an extracellular sulphydryl protease. This processing resulted in the production of multiple molecular-mass forms of each enzyme. Cells from early exponential phase cultures were susceptible to lysis(More)
A novel concept of Oxygen Saturation (SpO2) sensor embedded in a finger ring is presented in this paper. Due to the mechanical conception of the probe, the sensor fits any finger topology and assures a constant force applied to the phalanx. Ambient light artifacts are rejected at the analog electronics level. Finally, an innovative distribution of light(More)
This is a introduction to cellular automata stressing their role as standard-bearers of an aggressive form of reductionism|which we may term \\ne-grain modeling". Cellular automata try to capture in abstract computational terms certain fundamental aspects of physics|such as uniformity, locality, and local niteness. At the same time, precisely because of(More)
Mathematics has been described as the science of patterns. Natural science can be characterized as the investigation of patterns in nature. Central to both domains is the notion of model as a unit of coherently structured knowledge. Modeling Theory is concerned with models as basic structures in cognition as well as scientific knowledge. It maintains a(More)
In spite of the very common opinion we show that QM is not complete and that it is possible to create prequantum models providing finer description of physical reality than QM. There exists (at least in theoretical models) dispersion free states and the Heisenberg uncertainty principle can be violated. Thus in spite of all " No-Go " theorems Bell) we found(More)
concern in computer systems. The cessation of Dennard scaling has limited recent improvements in transistor speed and energy efficiency, resulting in slowed general-purpose processor improvements. Consequently , architectural innovation has become crucial to achieve performance and efficiency gains. 1 However, a tension exists between efficiency and(More)
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