Volkher Scharnhorst

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Studies on the molecular mechanisms underlying neuronal differentiation are frequently performed using cell lines established from neuroblastomas. In this study we have used mouse N1E-115 neuroblastoma cells that undergo neuronal differentiation in response to DMSO. During differentiation, cyclin-dependent kinase (cdk) activities decline and phosphorylation(More)
BACKGROUND New-generation high-sensitivity assays for cardiac troponin have lower detection limits and less imprecision than earlier assays. Reference 99th-percentile cutoff values for these new assays are also lower, leading to higher frequencies of positive test results. When cardiac troponin concentrations are minimally increased, serial testing allows(More)
AIM This study explores clinical outcome in cytochrome P450 2C19 (CYP2C19)-related poor metaboliser patients treated with either clopidogrel or prasugrel after percutaneous coronary intervention (PCI) and investigates whether this could be cost-effective. METHODS AND RESULTS This single-centre, observational study included 3260 patients scheduled for(More)
To the Editor: Preanalytical factors that affect para-thyroid hormone (PTH) concentrations are not well defined. Measured PTH concentrations in EDTA plasma may (1, 2) or may not (3) differ from those in serum. PTH has been reported variously to be stable for hours to days (1– 6). In addition, different PTH assays cross-react to various extents with(More)
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