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  • Florian Lang, Christoph Boehmer, Mònica Palmada, Guiscard Seebohm, Nathalie Strutz-Seebohm, Volker Vallon
  • Biology, Medicine
  • Physiological reviews
  • 2006 (First Publication: 1 October 2006)
  • The serum- and glucocorticoid-inducible kinase-1 (SGK1) is ubiquitously expressed and under genomic control by cell stress (including cell shrinkage) and hormones (including gluco- andContinue Reading
  • Tom Nijenhuis, Volker Vallon, AnneMiete W. van der Kemp, Johannes Loffing, Joost G. J. Hoenderop, René J M Bindels
  • Chemistry, Medicine
  • The Journal of clinical investigation
  • 2005 (First Publication: 1 June 2005)
  • Thiazide diuretics enhance renal Na+ excretion by blocking the Na+-Cl- cotransporter (NCC), and mutations in NCC result in Gitelman syndrome. The mechanisms underlying the accompanying hypocalciuriaContinue Reading
  • Valentin Gorboulev, Annette Schürmann, +20 authors Hermann Koepsell
  • Biology, Chemistry, Medicine
  • Diabetes
  • 2012 (First Publication: 12 December 2011)
  • To clarify the physiological role of Na(+)-D-glucose cotransporter SGLT1 in small intestine and kidney, Sglt1(-/-) mice were generated and characterized phenotypically. After gavage of d-glucose,Continue Reading
  • Scott Culver Thomson, Aihua Deng, De-guo Bao, J. H. Satriano, Roland C. Blantz, Volker Vallon
  • Medicine
  • The Journal of clinical investigation
  • 2001 (First Publication: 15 January 2001)
  • In early diabetes, the kidney grows and the glomerular filtration rate (GFR) increases. This growth is linked to ornithine decarboxylase (ODC). The study of hyperfiltration has focused onContinue Reading
  • Joost G. J. Hoenderop, Johannes P T M van Leeuwen, +8 authors René J M Bindels
  • Biology, Medicine
  • The Journal of clinical investigation
  • 2003 (First Publication: 15 December 2003)
  • Ca2+ ions play a fundamental role in many cellular processes, and the extracellular concentration of Ca2+ is kept under strict control to allow the proper physiological functions to take place. TheContinue Reading
  • Volker Vallon, K. Richter, Roland C. Blantz, Scott Thomson, Hartmut Osswald
  • Medicine
  • Journal of the American Society of Nephrology…
  • 1999 (First Publication: 1 December 1999)
  • An increase in Na+/glucose cotransport upstream to the macula densa might contribute to the increase in single nephron GFR (SNGFR) in early diabetes mellitus by lowering the signal of theContinue Reading