Volker Neumann

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OBJECTIVES The study group comprised a collective of 1,605 patients with malignant mesotheliomas and with lung tissue available for lung dust analyses. METHOD Clinical features, occupational histories, expositions and individual data were evaluated, and the asbestos bodies concentrations (asbestos bodies/cm3 lung tissue or g wet tissue) were determined.(More)
BACKGROUND The incidence of malignant mesothelioma in Germany is about 20 cases per million persons per year. Its association with asbestos exposure, usually occupational, has been unequivocally demonstrated. Even though the industrial use of asbestos was forbidden many years ago, new cases of mesothelioma continue to appear because of the long latency of(More)
Zwischen 1992 und 1998 wurden im Deutschen Mesotheliomregister 70 peritoneale maligne und 4 benigne Mesotheliome pathologisch-anatomisch diagnostiziert. Die malignen Mesotheliome sind überwiegend (55/70) bei Männern entwickelt, bei den benignen Veränderungen ist nur ein Mann betroffen. Das Erkrankungsalter der Patienten mit malignen Mesotheliomen liegt im(More)
A total of 70 malignant and 4 benign peritoneal mesotheliomas were diagnosed by the German Mesothelioma Registry between 1992 and 1998. Malignant mesotheliomas developed mainly in men (55/70); only one man had a benign peritoneal alteration. Age at first diagnosis of malignant mesotheliomas is about 59 years; the women are on average 4 years younger than(More)
Malignant mesothelioma is a rare aggressive tumour arising from mesothelial cells of the pleural and peritoneal cavity including pericardium and tunica vaginalis testis. Malignant mesothelioma occurs predominantly in men (>90%). Asbestos exposure is the best known and evaluated risk factor with a long latency period between exposure and onset of malignant(More)
The objective of this analysis was the estimation of the cancer risks of asbestos and asbestosis in a surveillance cohort of high-exposed German workers. A group of 576 asbestos workers was selected for high-resolution computer tomography of the chest in 1993-1997. A mortality follow-up was conducted through 2007. Standardised mortality ratios (SMRs) were(More)
Between 1987 and 2000, the German mesothelioma register recorded a total of 4,455 patients with malignant mesotheliomas. Survival times for 498 (11.2%) patients were available; 155 patients (study group, 3.5% of the total group) survived for more than 2 years and 343 patients (control group, 7.7% of the total group) survived for fewer than 24 months. Male(More)
BACKGROUND Pemetrexed-based chemotherapy represents the standard of care in first-line treatment of advanced malignant pleural mesothelioma (MPM). However, there are no established predictors of clinical benefit. Pemetrexed inhibits multiple enzymes involved in pyrimidine and purine synthesis, but the main target is thymidylate synthase (TS). After cellular(More)
The actinomycete bacterium Tropheryma whippelii has been identified as the presumed cause of morbus Whipple (4). A second Whipple’s disease-associated bacterial organism (WABO) was found in a duodenal biopsy specimen in a single case (2). DNA sequence data for the 16S rRNA gene place WABO evolutionarily close to the nocardioform bacteria. It is well-known(More)