Volker Hösel

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Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14(More)
Obesity is globally prevalent and highly heritable, but the underlying genetic factors remain largely elusive. To identify genetic loci for obesity-susceptibility, we examined associations between body mass index (BMI) and ~2.8 million SNPs in up to 123,865 individuals, with targeted follow-up of 42 SNPs in up to 125,931 additional individuals. We confirmed(More)
A population genetic model is used to describe dynamical aspects of chromosomal abberations observed in M-FISH experiments. Linear differential equations model the evolution of relative frequencies of mutations. The unknown parameters involved are estimated by maximum likelihood methods. We propose a scoring system to select the most important mutations. In(More)
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