Volker Buschmann

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BACKGROUND/AIMS QT-interval screens are increasingly important for cardiac safety on all new medications. So far, investigations rely on animal experiments or cell-based screens solely probing for conductance alterations in heterologously expressed hERG-channels in cell lines allowing for a high degree of automation. Adult cardiomyocytes can not be handled(More)
OBJECTIVE A novel high-precision approach [lifetime-decomposition measurement (LTDM)] for the assessment of the glomerular filtration rate (GFR) based on clearance measurements of exogenous filtration marker. METHODS The time-correlated single photon counting (TCSPC) acquisition in combination with a new decomposition method allows the separation of(More)
Fluorescence Correlation Spectroscopy (FCS) is used to determine concentrations and diffusion constants in the picoto nanomolar concentration region with broad applications in Biology and Chemistry. However, the method is correlated to a broad range of measurement parameters and other factors as background contributions which make quantitative results very(More)
During the last two decades, the use of fluorescence in natural sciences has propelled a number of research fields, ranging from biological sciences and applications in the clinical sector (FISH for genetic testing, advanced sequencing technology) to environmental monitoring. In addition, the resulting technological developments have become important in(More)
New integrated photon timing electronics with three independent input channels provide very short deadtime and very high throughput. We present design features and basic tests as well as application results from fluorescence and luminescence imaging.
Limitations in the sensitivity and dynamic range of two-dimensional gel electrophoresis (2-DE) are currently hampering its utility in global proteomics and biomarker discovery applications. In the current study, we present proof-of-concept analyses showing that introducing time-resolved fluorescence in the image acquisition step of in-gel protein(More)
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