Learn More
Rationale: Traumatic life events can induce long-term alterations in neuronal substrates, which may ultimately lead to the development of anxiety disorders. It has been postulated that corticotropin-releasing hormone (CRH) plays an important role in anxiety-like behavior. Objectives: (1) To study the long-term effects of a single foot-shock experience on(More)
Animal models of depression support a pathogenetic role for vasopressinergic activation involving increased arginine vasopressin (AVP) release and AVP receptor (V1b) synthesis. Evidence of this has been found particularly in patients with highly anxious-retarded (HAR) and above-normal AVP (ANA) depression. A general pathogenetic theory however predicts(More)
Any change in the social or physical environment that threatens the needs or interests of a mammal, induces a state of tension ('stress') in the animal. Driven by this tension, the animal changes its behaviour. At the same time, alterations occur in bodily functions. All organs and regulatory systems (central and peripheral nervous systems, endocrine and(More)
  • 1