Learn More
BACKGROUND Treatments with survival benefit are greatly needed for women with heavily pretreated metastatic breast cancer. Eribulin mesilate is a non-taxane microtubule dynamics inhibitor with a novel mode of action. We aimed to compare overall survival of heavily pretreated patients receiving eribulin versus currently available treatments. METHODS In(More)
Software instrumentation is a powerful and flexible technique for analyzing the dynamic behavior of programs. By inserting extra code in an application, it is possible to study the performance and correctness of programs and systems. Pin is a software system that performs run-time binary instrumentation of unmodified applications. Pin provides an API for(More)
PURPOSE An open-label, noninferiority study to evaluate the impact of epoetin alfa (EPO) on tumor outcomes when used to treat anemia in patients receiving chemotherapy for metastatic breast cancer. METHODS Women with hemoglobin ≤ 11.0 g/dL, receiving first- or second-line chemotherapy for metastatic breast cancer, were randomly assigned to EPO 40,000 IU(More)
The objective of this study was to assess the efficacy and tolerability of YM155, a survivin suppressor, in combination with docetaxel, compared with docetaxel alone in patients with HER2-negative metastatic breast cancer. This phase II, multicenter, open-label, 2-arm study randomized patients (≥18 years) with histologically or cytologically confirmed stage(More)
Cetuximab in combination with an irinotecan-containing regimen is a standard treatment in patients with KRAS wild-type (KRAS WT), metastatic colorectal cancer (mCRC). We investigated the addition of the oral MET inhibitor tivantinib to cetuximab + irinotecan (CETIRI) based on preclinical evidence that activation of the MET pathway may confer resistance to(More)
The paper reports on the formal framework to design strategies for multi-issue non-symmetric meaning negotiations among software agents in a distributed information retrieval system. The advancements of the framework are the following. A resulting strategy compares the contexts of two background domain theories not concept by concept, but the whole context(More)
Reported is the methodology of the semantic transformation of an initial user's search query in the form of key words or key phrases to the resulting query composed of the relevant concepts of the domain ontology. Transformation methodology is based on incremental user profiling. The mapping of a user's keywords to the concepts of the domain ontology is(More)
We develop a theory of acquisition timing and means of payment when potential acquirers are financially constrained. Bidders with private valuations choose when to approach the target and whether to bid in cash or stock. A bidder's ability to pay cash is limited by a cash constraint. We solve for the equilibrium initiation strategies and study the(More)
An ontology, if used for practical purposes like in information systems, contains its controlled vocabulary (TBox) describing the semantics of the domain and the set of facts (ABox) about this domain. The elements of the ABox are ontology instances. If a domain is described by two or more different ontologies or if ontologies evolve, TBoxes are the first(More)