Vladimir V Barynin

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FtsZ is an essential bacterial guanosine triphosphatase and homolog of mammalian beta-tubulin that polymerizes and assembles into a ring to initiate cell division. We have created a class of small synthetic antibacterials, exemplified by PC190723, which inhibits FtsZ and prevents cell division. PC190723 has potent and selective in vitro bactericidal(More)
The crystal structure of the bacterial catalase from Micrococcus lysodeikticus has been refined using the gene-derived sequence both at 0.88 A resolution using data recorded at 110 K and at 1.5 A resolution with room-temperature data. The atomic resolution structure has been refined with individual anisotropic atomic thermal parameters. This has revealed(More)
The three-dimensional crystal structure of catalase from Micrococcus lysodeikticus has been solved by multiple isomorphous replacement and refined at 1.5 A resolution. The subunit of the tetrameric molecule of 222 symmetry consists of a single polypeptide chain of about 500 amino acid residues and one haem group. The crystals belong to space group(More)
  • E Coli, D J G Stubbe, C S Nocera, M C Y Yee, Chem Chang, M Zheng +13 others
  • 2008
in response to oxidative stress of a Mn-dependent paralog to the constitutively expressed , Fe-dependent superoxide dismutase (30). Examination of the reactivity of the distinctive Mn/Fe cofactor toward these oxidants may thus provide a biochemical rationale for its evolution. rich medium had the same iron content as preparations from iron-supplemented(More)
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