Vladimir Rohan

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INTRODUCTION Glioblastoma multiforme (GBM) is the most malignant primary brain tumor in adults. Recent whole-genome studies revealed novel GBM prognostic biomarkers such as mutations in metabolic enzyme IDH-isocitrate dehydrogenases (IDH1 and IDH2). The distinctive mutation IDH1 R132H was uncovered to be a strong prognostic biomarker for glioma patients. We(More)
Primary and secondary prevention of ischemic stroke represents a significant part of stroke management and health care. Although there are official guidelines concerning stroke management, new knowledge are introduced to them with a slight delay. This article provides an overview of current information on primary and secondary prevention of ischemic stroke.(More)
Glioblastoma multiforme (GBM) is the most malignant brain tumor in adults, exhibiting high mortality. Standard therapy (surgery, radiotherapy and chemotherapy with temozolomide) has only limited effectiveness. The progress in genomics regarding GBM, in the detection of new markers of oncogenesis, abnormalities in signalling pathways, tumor microenvironment,(More)
BACKGROUND AND PURPOSE The length of large vessel occlusion is considered a major factor for therapy in patients with ischemic stroke. We used 4D-CT angiography evaluation of middle cerebral artery occlusion in prediction of recanalization and favorable clinical outcome and after intravenous thrombolysis (IV-tPA). METHODS In 80 patients treated with(More)
Oligodendrogliomas are uncommon tumors in neurooncology that represent about 5% of primary brain malignancies. Their high sensitivity to radiotherapy and chemotherapy was observed a long time ago. Nonetheless, the evidence-based proof of the significantly longer survival in patients with oligodendrogliomas treated with combined chemotherapy and radiotherapy(More)
BACKGROUND Anaplastic oligodendrogliomas (AO) are rare tumors. Two phase III clinical trials (RTOG 9402 and EORTC 26951) proved favorable effects of radiotherapy (RT) with chemotherapy (procarbazine, lomustine and vincristine; PCV) in patients with AO carrying chromosomal mutation of co-deletion1p/19q even if it was not the primary endpoint of these(More)
Cerebrovascular diseases are one of the most common causes of death worldwide. In this paper, we analyze relationships in heterogeneous collaborating centre's medical data to resolve a solution of this complex problem. Data mining is primarily based on clinical data, imaging examinations and therapeutic data stored in various data formats. The raw and mined(More)
The cerebrovascular diseases research are based on deidentified real patient's data received from a collaborating centre. The goal of research is to take advantage of heterogeneous medical data relationships. Medical data relationships leads to get more data mining facilities in studying of dependencies and crucial values of parameters in a huge volume of(More)
The most indicated imaging technique before operations is computed tomography. Preoperative deliberation requires not only its own evaluation of pathological findings, but also the overall anatomy, perfusion and volume of various anatomical parts, which must be accurately identified. There is a wide range for computer-assisted diagnosis, which should reduce(More)
We provide an overview of the association between vitamin D and some neurological diseases where the correlation has repeatedly been described. The majority of literature refers to cerebrovascular diseases, followed by multiple sclerosis and cognitive disorders. Vitamin D hypovitaminosis might be associated with the diseases directly or it might contribute(More)