Vladimir Rohan

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INTRODUCTION Glioblastoma multiforme (GBM) is the most malignant primary brain tumor in adults. Recent whole-genome studies revealed novel GBM prognostic biomarkers such as mutations in metabolic enzyme IDH-isocitrate dehydrogenases (IDH1 and IDH2). The distinctive mutation IDH1 R132H was uncovered to be a strong prognostic biomarker for glioma patients. We(More)
malignant brain tumor in adults, exhibiting high mortality. Standard therapy (surgery, radiotherapy and chemotherapy with temozolomide) has only limited effectiveness. The progress in genomics regarding GBM, in the detection of new markers of oncogenesis‚ abnormalities in signalling pathways, tumor microenvironment, and pathological angiogenesis over the(More)
Cerebrovascular disease is the third main cause of death and the leading cause of disablement in the Czech Republic. The incidence of stroke is higher than in Western European countries and is one of causes of lower average age in this country. The data of 15880 stroke patients who entered into the IKTA stroke register from 13 Czech stroke centres in the(More)
Primary brain tumors form an important public health problem. There were more than 66,000 cases diagnosed in the US in 2012 with 13,700 deaths. The most malignant primary brain tumor in adults-Glioblastoma multiforme (GBM)-is extremely aggressive and invasive cancer, difficult to surgery with high resistance to standard radiother-apy and chemotherapy. The(More)
PURPOSE Thrombolytic therapy in patients with acute ischemic stroke is contraindicated when the infarction core exceeds a given threshold. To date, there are no standardized guidelines for computed tomography infarction core assessment. Current practice involves use of thresholding methods, where the results are further adjusted by an experienced physician.(More)