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INTRODUCTION Glioblastoma multiforme (GBM) is the most malignant primary brain tumor in adults. Recent whole-genome studies revealed novel GBM prognostic biomarkers such as mutations in metabolic enzyme IDH-isocitrate dehydrogenases (IDH1 and IDH2). The distinctive mutation IDH1 R132H was uncovered to be a strong prognostic biomarker for glioma patients. We(More)
Glioblastoma multiforme (GBM) is the most malignant brain tumor in adults, exhibiting high mortality. Standard therapy (surgery, radiotherapy and chemotherapy with temozolomide) has only limited effectiveness. The progress in genomics regarding GBM, in the detection of new markers of oncogenesis, abnormalities in signalling pathways, tumor microenvironment,(More)
Primary and secondary prevention of ischemic stroke represents a significant part of stroke management and health care. Although there are official guidelines concerning stroke management, new knowledge are introduced to them with a slight delay. This article provides an overview of current information on primary and secondary prevention of ischemic stroke.(More)
Cerebrovascular diseases are one of the most common causes of death worldwide. In this paper, we analyze relationships in heterogeneous collaborating centre's medical data to resolve a solution of this complex problem. Data mining is primarily based on clinical data, imaging examinations and therapeutic data stored in various data formats. The raw and mined(More)
A1 Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma Jella-Andrea Abraham, Olga Golubnitschaja A2 Integrated market access approach amplifying value of “Rx-CDx” Ildar Akhmetov A3 Disaster response: an opportunity to improve global healthcare Russell J. Andrews,(More)
PURPOSE To assess the benefit of 4D-CT angiography (4D-CTA) in determination and precise measurement of middle cerebral artery (MCA) occlusion in comparison to CTA. Possible relationship of measured occlusion lengths with recanalization after intravenous thrombolysis was analysed as a second objective. METHODS Detailed evaluation of complete MCA(More)
Cerebrovascular disease is the third main cause of death and the leading cause of disablement in the Czech Republic. The incidence of stroke is higher than in Western European countries and is one of causes of lower average age in this country. The data of 15880 stroke patients who entered into the IKTA stroke register from 13 Czech stroke centres in the(More)
Primary brain tumors form an important public health problem. There were more than 66,000 cases diagnosed in the US in 2012 with 13,700 deaths. The most malignant primary brain tumor in adults-Glioblastoma multiforme (GBM)-is extremely aggressive and invasive cancer, difficult to surgery with high resistance to standard radiother-apy and chemotherapy. The(More)
PURPOSE Thrombolytic therapy in patients with acute ischemic stroke is contraindicated when the infarction core exceeds a given threshold. To date, there are no standardized guidelines for computed tomography infarction core assessment. Current practice involves use of thresholding methods, where the results are further adjusted by an experienced physician.(More)