Vladimir Rohan

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INTRODUCTION Glioblastoma multiforme (GBM) is the most malignant primary brain tumor in adults. Recent whole-genome studies revealed novel GBM prognostic biomarkers such as mutations in metabolic enzyme IDH-isocitrate dehydrogenases (IDH1 and IDH2). The distinctive mutation IDH1 R132H was uncovered to be a strong prognostic biomarker for glioma patients. We(More)
Glioblastoma multiforme (GBM) is the most malignant brain tumor in adults, exhibiting high mortality. Standard therapy (surgery, radiotherapy and chemotherapy with temozolomide) has only limited effectiveness. The progress in genomics regarding GBM, in the detection of new markers of oncogenesis, abnormalities in signalling pathways, tumor microenvironment,(More)
Primary and secondary prevention of ischemic stroke represents a significant part of stroke management and health care. Although there are official guidelines concerning stroke management, new knowledge are introduced to them with a slight delay. This article provides an overview of current information on primary and secondary prevention of ischemic stroke.(More)
Cerebrovascular diseases are one of the most common causes of death worldwide. In this paper, we analyze relationships in heterogeneous collaborating centre's medical data to resolve a solution of this complex problem. Data mining is primarily based on clinical data, imaging examinations and therapeutic data stored in various data formats. The raw and mined(More)
The MetaMed is a tool for data and meta data extraction primarily from a heterogeneous medical data. It is a non-interactive command line open source application for processing a large amount of data. An extracted meta data is stored in the Resource Description Framework and is structured by OWL ontologies. It enables a semantic interoperability. Meta data(More)
PURPOSE Thrombolytic therapy in patients with acute ischemic stroke is contraindicated when the infarction core exceeds a given threshold. To date, there are no standardized guidelines for computed tomography infarction core assessment. Current practice involves use of thresholding methods, where the results are further adjusted by an experienced physician.(More)