Vladimir Pochuev

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The aim of the present study was to examine the changes in the proteome profile of the blood serum in seven Russian cosmonauts after long-term space missions aboard International Space Station. Blood was sampled 45–60 days prior to and 1 and 7 days after the end of the mission. One day after the end of vmission, we found a decrease in the peaks of(More)
INTRODUCTION The medical community of the International Space Station (ISS) has developed joint medical standards and evaluation requirements for Space Flight Participants ("space tourists") which are used by the ISS medical certification board to determine medical eligibility of individuals other than professional astronauts (cosmonauts) for short-duration(More)
BACKGROUND A total of eight commercial spaceflight participants have launched to the International Space Station (ISS) on Soyuz vehicles. Based on an older mean age compared to career astronauts and an increased prevalence of medical conditions, spaceflight participants have provided the opportunity to learn about the effect of space travel on crewmembers(More)
Purpose of the study was to track permanent proteins of urine proteome in the 520-day isolation experiment at the IBMP Ground-Based Test Facility with controlled environmental parameters. Object of the investigation was urine sampled from 6 normal male subjects at the age of 25 to 37 years. Second morning aliquots were gathered during baseline data(More)
SPECIFIC AIMS to evaluate the influence of the use thigh cuffs "Bracelet" on the hemodynamic adaptation to microgravity during short-term (up to a month) space flights, in-flight tolerance to LBNP-tests and post-flight orthostatic tolerance. 6 cosmonauts applied and 7 others did not apply the occlusive cuffs when on flight. The "Bracelet" device notably(More)
We analyzed protein profile of urine samples obtained from 7 Russian cosmonauts (age 35-51 years), participants of space flights on the International Space Station lasting for 169-199 days. Gradient chromatography with linear increase of eluent proportion was carried out in a system consisting of an Agilent 1100 chromatograph (Agilent Technologies Inc.) and(More)
Comparative investigation of the hemodynamic responses of cosmonauts at rest, during occlusive leg plethysmography, and LBNP in relatively short (less than a month) space flights were performed to tie up these measurements with post-landing orthostatic stability (OS). The decreased LBNP tolerance in flight that correlated later on with impaired reactions to(More)
Orthostatic tolerance (OT) was evaluated in 25 cosmonauts using the traditional standing test before and after space fights of about six months in length; 15 cosmonauts of this group were also subjected to ultrasonic investigation during the lower body negative pressure test before, during and after long-term SF. Efficiency of the OT vascular mechanisms was(More)
According to the analysis of the data of active and passive orthostatic tolerance (OST) testing before and after 67 short- (SSF) and 53 long-term (LSF) space flights OST declined in all the cosmonauts regardless of flight length. Active testing on R+1 after SSF (7 to 25 d) and LSF (49 to 438 d) attested OST loss by 33% and 48%, respectively. Full OST(More)