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- Vladimir P. Dragalin, Alexander G. Tartakovsky, Venugopal V. Veeravalli
- IEEE Trans. Information Theory
- 1999

The problem of sequential testing of multiple hypotheses is considered, and two candidate sequential test procedures are studied. Both tests are multihypothesis versions of the binary sequentialâ€¦ (More)

{ The problem of sequential testing of multiple hypotheses is considered, and two candidate sequential test procedures are studied. Both tests are multihypothesis versions of the binary sequentialâ€¦ (More)

- Vladimir P. Dragalin, Alexander G. Tartakovsky, Venugopal V. Veeravalli
- IEEE Trans. Information Theory
- 2000

In a companion paper [13], we proved that two specific constructions of multihypothesis sequential tests, which we refer to as Multihypothesis Sequential Probability Ratio Tests (MSPRTâ€™s), areâ€¦ (More)

- Paul P. Gallo, Christy Chuang-Stein, Vladimir P. Dragalin, Brenda L Gaydos, Michael Krams, JosÃ© Pinheiro
- Journal of biopharmaceutical statistics
- 2006

A PhRMA Working Group on adaptive clinical trial designs has been formed to investigate and facilitate opportunities for wider acceptance and usage of adaptive designs and related methodologies. Aâ€¦ (More)

{ The problem of sequential testing of multiple hypotheses is considered, and two candidate sequential test procedures are studied. Both tests are multihypothesis versions of the binary sequentialâ€¦ (More)

We propose a new adaptive procedure for dose-finding in clinical trials with combination of two drugs when both efficacy and toxicity responses are available. We model the distribution of thisâ€¦ (More)

- Vladimir P. Dragalin, Valerii V. Fedorov, Yuehui Wu
- Statistics in medicine
- 2008

We introduce a two-stage design for dose-finding in the context of Phase I/II studies, where two binary correlated endpoints are available, for instance, one for efficacy and one for toxicity. Theâ€¦ (More)

- Kaushal Pandya, Richard F. Raubertas, +6 authors G. R. Morrow
- Annals of internal medicine
- 2000

BACKGROUND
Hot flashes are the most frequently reported side effect of tamoxifen treatment. Although hormones are an effective treatment, their safety is questionable in women with breast cancer. Itâ€¦ (More)

- Vladimir P. Dragalin, Valerii Fedorov
- Statistics in medicine
- 2006

We propose a correlated beta-binomial model for the binary response in multi-centre trials. The likelihood function in this case has a closed-form and we avoid multivariate numerical integrations inâ€¦ (More)

- Sudharshan Krishna Padmanabhan, Vladimir P. Dragalin
- Biometrical journal. Biometrische Zeitschrift
- 2010

We introduce a new optimal design for dose finding with a continuous efficacy endpoint. This design is studied in the context of a flexible model for the mean of the dose-response. The designâ€¦ (More)