Vladimir P Nikitin

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Experiments on the common snail were performed to study the influences of serotonin and glutamate receptor antagonists on the processes of reactivation of an associative habit consisting of refusing a particular type of food. Twenty-four hours after training, animals were injected with the non-selective serotonin receptor antagonist methiothepin (0.1(More)
We found previously that the inhibition of NMDA glutamate receptors during food aversion conditioning reactivation initiated disruption of long-term memory. In this work the dynamics of amnesia development was investigated. MK-801 (NMDA receptor antagonist) was injected into snail body cavity 24 hours after food aversion conditioning and conditioned food(More)
According to current concepts, long-term memory is based on structural-functional changes in particular synaptic connections between neurons in the brain (synapse-specific plasticity), which depend on the processes of translation and transcription. Studies on neurons in the mollusk Aplysia and the mammalian hippocampus have addressed a mechanism of(More)
Involvement of neurotransmitter receptors and translation and transcription processes in reconsolidation of conditioned food aversion memory was investigated in experiments on edible snails. Injections of neurotransmitter receptor antagonists and protein synthesis inhibitors before the reminder session were found to induce amnesia that was characterized by(More)
Effects of protein synthesis inhibitors on reactivation processes of food aversion conditioning were inverstigated in snail Helix lucorum. Protein synthesis inhibitor (PSI, anisomycin, 0.4 mg, or cycloheximede, 0.6 mg) was injected into snail body cavity 24 hours after 3-day training; then conditioned stimulus (banana) was presented and memory was tested.(More)
Electrophysiological parameters and bound calcium (Ca(b)) level dynamics during sensitization development or conditioning of food aversion were studied in the command neurons of defense behaviour in the snail Helix lucorum. Responses evoked by a testing sensory stimulus were facilitated 50-60 min after the first sensitizing stimulation, while conditioned(More)
We studied the involvement of translation and transcription processes into behavioral and neuronal mechanisms of reconsolidation of the long-term memory of the conditioned taste aversion in edible snails. Injection of cycloheximide (an inhibitor of protein synthesis) to the snails in 48 h after training combined with subsequent reminder and presentation of(More)
Memory is destabilized during retrieval-induced reconsolidation and can therefore be disrupted or modified. In the present study, we examined the role of translation and transcription processes in long-term food aversion memory reconsolidation in the snail Helix lucorum. The administration of the protein synthesis inhibitor anisomycin followed by a(More)
Current considerations suggest that the mechanisms of long term memory are based on the changes of the neuronal genetic algorithms. Process of the enzyme DNA methylation have great importance to the differential genes expression, and is likely to be one of the key mechanisms of the consolidation and memory storage. The present study aimed to investigate the(More)
Defensive behavior command neurons LP11 and RP11 were studied in semi-intact snail preparations to investigate the effects of N-methyl-D-aspartate (NMDA) receptor antagonists on the mechanisms of nociceptive sensitization. Application of sensitizing stimuli to the heads of control snails led to membrane depolarization and increased excitability, and also(More)