Vladimir Maiorov

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We previously reported that lysozyme accounts for anti-HIV activity associated with the beta-core fraction of human chorionic gonadotropin [Lee-Huang, S., Huang, P. L., Sun, Y., Kung, H. F., Blithe, D. L. & Chen, H. C. (1999) Proc Natl Acad Sci U S A 96, 2678-81]. To define the structural and sequence requirements for anti-HIV activity, we carried out(More)
The octapeptide corresponding to human interferon-alpha 2 (Hu IFN-alpha 2) sequence 131-138 has high affinity to murine thymocyte receptors (Kd = 4.2 x 10(-12) M, about 700 receptors per cell). The peptide receptor binding is inhibited by both Hu rIFN-alpha 2 (Ki = 8.6 x 10(-10) M) and thymosin-alpha 1 (TM-alpha 1) (Ki = 3 x 10(-7) M) as well as by the(More)
The analysis of the antigenic structure of human interferon (IFN)-alpha 1 with a panel of monoclonal antibodies revealed four immunodominant regions. Three of them, recognized by 12 of 14 antibodies were mapped into the aminoterminal portion of IFN-alpha 1 around residues 31-38, 43-53 and 63-85. The region 31-85 proved important also for the antiviral and(More)
A kinetic model of ionization waves in the inert gas discharge is constructed, which is based on the simultaneous solution of the kinetic equation for electrons and the continuity equations for ions and excited atoms. The model corresponds to a range of intermediate pressures and small currents, when elastic collisions dominate in the electron energy(More)
The octapeptide Gly-Lys-Val-Leu-Lys-Lys-Arg-Arg (termed leukocorticotropin, LCT) corresponding to the ACTH-like sequence 81-88 of human pro-interleukin-1 alpha and its derivative Tyr-Gly-Lys-Val-Leu-Lys-Lys-Arg-Arg were synthesized. The 125I-labeled Tyr-LCT specifically interacts with one type of receptor on the surface of murine splenocytes (Kd = (1.45 +/-(More)
The effects of human recombinant tumor necrosis factor and its peptides on the macrophage-like cells of continuous cell line P388D1 were studied. One of the peptides, 123–131, was found capable of not only mimicking, but also of blocking the effects of recombinant tumor necrosis factor. The results permit us to tentatively identify the 123–131 site of the(More)
Immunologically less reactive but functionally relevant structures were identified on human interferon (IFN)-alpha 2 by three neutralizing monoclonal antibodies (mAb). The binding sites of these mAbs were mapped using a set of synthetic peptides that covered the amino acid sequence of two predicted biologically active segments in the regions 31-53 and 63-85(More)
To order the complete compilation report, use: ADA421147 The component part is provided here to allow users access to individually authored sections f proceedings, annals, symposia, etc. However, the component should be considered within-he context of the overall compilation report and not as a stand-alone technical report. A homogeneous atmospheric(More)
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