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Flaviviral diseases, including dengue fever, West Nile fever, yellow fever, tick-borne encephalitis, Omsk haemorrhagic fever, and Powassan encephalitis, threaten human health all over the world. Lack of effective antivirals targeting replication cycle of flaviviruses makes the search of such compounds a challenging task. Recently we have identified a(More)
22 The NmethyllDaspartic acid (NMDA) receptor, along with kainic acid and aminoo33hydroxyy55 methyll44isoxazolepropionic acid (AMPA) receptors, belongs to the large family of glutamateegated ion channels involved in many important neurophysiologg ical processes in the central nervous system associated with fast synaptic excitation transmission, memory(More)
Flaviviral infections affect millions of people throughout the world, in such different territories as Europe, Aus-tralia, USA, and China. Among these infections are den-gue fever, tick-borne encephalitis, Powassan encephalitis, West Nile fever, yellow fever, Omsk haemorrhagic fever, etc. Effective vaccines exist against only several flavi-viruses.(More)
A possible mechanism of action of the allosteric modulators of NMDA (N-methyl-d-aspartate) receptors is proposed that involves the stabilization of the twisted closed-clamshell configuration of the amino-terminal domains of GluN1 and GluN2B subunits by negative modulators while positive modulators stabilize a roughly parallel tight arrangement of these(More)
A molecular model of mature dengue virus envelope building block consisting of two E and two M protein subunits is constructed. Monte Carlo optimisation is performed for the model in the implicit membrane system. Interactions between the ectodomains and membrane parts of E and M proteins are studied, and possible role of conserved residues is suggested. The(More)
NMethyllDaspartic acid (NMDA) receptor, belonging to the group of glutamate ionotropic recepp tors, is a very important biological target. It is involved in many significant neurophysiological processes in the central nervous system associated with the transfer of fast synaptic excitation, formation of memory, etc. Hyperactivation of NMDA receptor leads to(More)
In the volume PC market, the demand is growing for general-purpose processors that facilitate visual and graphical computing on the Internet. Responding to this need, Intel developed the streaming SIMD extensions (SSE), a set of processor instructions designed to boost performance of multimedia and Internet applications, and implemented them on its Pentium(More)