Vladimir M. Mikhailovich

Learn More
BACKGROUND The steady rise in the spread of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) requires rapid and reliable methods to identify resistant strains. The current molecular methods to detect MTB resistance to second-line drugs either do not cover an extended spectrum of mutations to be identified or are(More)
BACKGROUND Influenza A viruses are classified into subtypes depending on the antigenic properties of their two outer glycoproteins, hemagglutinin (HA) and neuraminidase (NA). Sixteen subtypes of HA and nine of NA are known. Lately, the circulation of some subtypes (H7N7, H5N1) has been closely watched because of the epidemiological threat they present. (More)
4 Influenza virus A is the most common cause of acute respiratory viral infections in humans. Accordd ing to the World Health Organization, severe complii cation cases are registered each year in 3–5 million people, and the number of lethal outcomes may reach 500 000 [1]. In the treatment of influenza, two groups of drugs currently have the greatest(More)
Steadily growing resistance of the tuberculosis causative agent towards a broad spectrum of antituberculosis drugs calls for rapid and reliable methods for identifying the genetic determinants responsible for this resistance. In this study, we present a biochip-based method for simultaneous identification of mutations within rpoB gene associated with(More)
  • Vyacheslavevich Zinoviev, Nikolai Alexandrovich Vasilyev, Vladimir Mikhailovich, Sergey Sergeyvich Shavrin
  • 2014
The logical-probabilistic models of survivability of information systems (IS) are studied, on the basis of the models method of analysis of survivability with drawing logical dependencies of the system from the adverse impacts is offered; it is demonstrated that survivability feature significantly differs from the reliability, durability and other(More)
Р а с с м о т р е н ы в о п р о с ы с и н т е з а п с е в д о с л у ч а й н о й ф у н к ц и и п о в ы ш е н н о й э ф ф е к т и в н о-с т и. Д о к а з а н о , ч т о п с е в д о с л у ч а й н а я ф у н к ц и я м о ж е т б ы т ь п о с т р о е н а н а о с н о в е к а с к а д н о й с х е м н о й р е а л и з а ц и и. П о л у ч е н н ы е р е з у л ь т а т ы с в и(More)
  • 1