Vladimir Ilin

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The abilities of neuronal populations to encode rapidly varying stimuli and respond quickly to abrupt input changes are crucial for basic neuronal computations, such as coincidence detection, grouping by synchrony, and spike-timing-dependent plasticity, as well as for the processing speed of neuronal networks. Theoretical analyses have linked these(More)
Adenosine is a wide-spread endogenous neuromodulator. In the central nervous system it activates A1 and A2A receptors (A1Rs and A2ARs) which have differential distributions, different affinities to adenosine, are coupled to different G-proteins, and have opposite effects on synaptic transmission. Although effects of adenosine are studied in detail in(More)
Understanding of how neurons transform fluctuations of membrane potential, reflecting input activity, into spike responses, which communicate the ultimate results of single-neuron computation, is one of the central challenges for cellular and computational neuroscience. To study this transformation under controlled conditions, previous work has used a(More)
UNLABELLED Hebbian-type learning rules, which underlie learning and refinement of neuronal connectivity, postulate input specificity of synaptic changes. However, theoretical analyses have long appreciated that additional mechanisms, not restricted to activated synapses, are needed to counteract positive feedback imposed by Hebbian-type rules on synaptic(More)
Accurately describing synaptic interactions between neurons and how interactions change over time are key challenges for systems neuroscience. Although intracellular electrophysiology is a powerful tool for studying synaptic integration and plasticity, it is limited by the small number of neurons that can be recorded simultaneously in vitro and by the(More)
KEY POINTS Adenosine might be the most widespread neuromodulator in the brain, but its effects on inhibitory transmission in the neocortex are not understood. Here we report that adenosine suppresses inhibitory transmission to layer 2/3 pyramidal neurons via activation of presynaptic A1 receptors. We present evidence for functional A2A receptors, which have(More)
H IGH-POWER electric propulsion thrusters can reduce propellant mass for heavy-payload orbit-raising missions and cargo missions to the moon and near-Earth asteroids, and they can reduce the trip time of robotic and piloted planetary missions [1–4]. The Variable Specific Impulse Magnetoplasma Rocket (VASIMR®) VX-200 engine is an electric propulsion system(More)
It is shown that the stay of deep-sea divers under high-altitude conditions causes a significant improvement in functional state of their breathing system. The speed and degree of lung ventilatory function restitution under conditions of mountain climate are higher than in other climatic zones. The positive effects of staying in the mountains are stable and(More)