Vladimir I. Pavlov

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BACKGROUND Pelvic pain is a major component of the morbidity associated with urinary tract infection (UTI), yet the molecular mechanisms underlying UTI-induced pain remain unknown. UTI pain mechanisms probably contrast with the clinical condition of asymptomatic bacteriuria (ASB), characterized by significant bacterial loads without lack symptoms. METHODS(More)
It is reported that PTP1B limits cytokine signaling in vitro. However, PTP1B's function during inflammation in vivo is not known. In this report, we determined whether PTP1B deficiency affects allergic inflammation in vivo. Briefly, lungs of OVA-challenged PTP1B(-/-) mice had elevated numbers of eosinophils and eosinophil progenitors at 6 h after one OVA(More)
PURPOSE Interstitial cystitis/painful bladder syndrome is a chronic bladder inflammatory disease of unknown etiology that is often regarded as neurogenic cystitis. The condition is associated with focal inflammation, urothelial lesions, voiding dysfunction and pain in the pelvic/perineal area. Approximately 90% of patients with the condition are women,(More)
The molecular initiators of infection-associated pain are not understood. We recently found that uropathogenic E. coli (UPEC) elicited acute pelvic pain in murine urinary tract infection (UTI). UTI pain was due to E. coli lipopolysaccharide (LPS) and its receptor, TLR4, but pain was not correlated with inflammation. LPS is known to drive inflammation by(More)
This paper applies the Hamiltonian Approach (HA) to two-dimensional motions of incompressible fluid in curvilinear coordinates, in particular on a sphere. The HA has been used to formulate governing equations of motion and to interpret the evolution of a system consisting of N localized two-dimensional vortices on a sphere. If the number of vortices N is(More)
Two-dimensional vortex pairs are frequently observed in geophysical conditions, for example, in a shelf zone of the ocean near river mouths. The main aims of the work are to estimate the space scales of such vortex structures, to analyze possible scenarios of vortex pair motion and to give the qualitative classification of their trajectories. We discuss(More)
An overall picture of the Venusian hot spots phenomenon is considered in the framework of the simplest conceptual models that admit the solutions in the form of steadily rotating "hot" vortices. Model assumptions take into account only those features of the middle atmosphere in the polar region of Venus that are supported by observational data and are(More)
The impaired production of INFs and of other cytokines at different stages of their synthesis in patients with genital herpes before and after treatment were shown to reflect the specificity of the immune response in the mentioned pathology. An activation of the cellular and humoral immunity according to the Th1 and Th2 types was observed in patients with(More)
We formulate the Hamiltonian version of contour dynamics for a model of axially symmetric, equally vortexed jet streams with a free boundary. In particular, we study dominant structural elements which appear in strongly perturbed jet streams at the stage of their decay. The model produces solutions with compact support which can describe such dominant(More)