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The role of Epstein-Barr virus (EBV), ubiquitous lymphotropic human herpesvirus 4, in etiology of nasopharyngeal carcinoma (NPC) has not been completely clarified. The mechanism of carcinogenesis in this disease (closely associated with EBV) is also unclear. The aim of the present study was to compare the structure of the LMP1 oncogene of EBV in isolates of… (More)
neider for excellent technical assistance and Martin Pfeffer and Holger Scholz for editorial help.
It is well known that the Epstein–Barr virus (EBV) is a widespread infection in the human population. Typically, infection occurs in early childhood without serious consequences for infected people. At the same time, a secondary infection with an additional EBV strain occurs quite often. During the in vitro cultivation of peripheral blood lymphocytes from… (More)
Epstein–Barr virus (EBV) is an etiological agent of a number of human benign and malignant tumors, including infectious mononucleosis (IM), Burkitt lymphoma (BL), Hodgkin lymphoma (HL), non-Hodgkin lymphomas (NLHs), nasopharyngeal carcinoma (NPC), among others. Latent membrane protein 1 (LMP1) encoded by the gene of the same name (LMP1) is the main… (More)