Vladimir Fedorov

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The effect of cardiac glycosides to increase cardiac inotropy by altering Ca(2+) cycling is well known but still poorly understood. The studies described in this report focus on defining the effects of ouabain signaling on sarcoplasmic reticulum Ca(2+)-ATPase function. Rat cardiac myocytes treated with 50 microM ouabain demonstrated substantial increases in(More)
It has been discovered in experiments on rats with traumatic paralysis of the sciatic nerve that a methacrylic acid derivative, beta-aminoethylmethacrylate (AEM), displays marked neurotropic, particularly strychnine-like activity. Using visual, electrophysiological and biochemical research methods it has been demonstrated that the substance has a(More)
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