Vladica Dimitrov

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BACKGROUND Bilastine is a novel, nonsedating H(1)-antihistamine developed for symptomatic treatment of Allergic Rhinitis and Chronic Idiopathic Urticaria. The objective of this study was to compare the efficacy and safety of bilastine 20 mg vs placebo and desloratadine 5 mg in subjects with seasonal allergic rhinitis (SAR). METHODS This randomized, double(More)
A study of the argentophilic structures of the miracidium of the strigeid digenean Strigea falconispalumbi VIBORG, 1795 was carried out. Miracidia were hatched under laboratory conditions from eggs obtained from adult S. falconispalumbi from the intestine of a naturally infected Buzzard (Buteo buteo). Miracidia were stained with 0.5%. Silver Nitrate(More)
For the first time in Bulgaria a case is reported of facial melanoma metastases in the vagal nerve. They were successfully removed together with cervical lymph dissection. Surgical treatment was followed by radiotherapy and chemotherapy. Control check up one year after the operation failed to disclose relapse or new metastases.
A detailed observation of the sensory apparatus of Opisthioglyphe ranae (Frölich, 1791) cercariae was carried out. The species was determined on the basis of an experimental study of the life cycle and morphology of sporocysts, cercariae, metacercariae, and adults. In contrast to other species of the family Plagiorchidae, no papillae were present in the(More)
In order to provoke an immune response, a tumor vaccine should not only maximize antigen-specific signals, but should also provide the necessary "co-stimulatory" environment. One approach is to genetically manipulate tumor cells to either secrete lymphokines (GM-CSF, IL-12, IL-15) or express membrane bound molecules (CD80, CD86). Furthermore, patient(More)
The histamine-induced wheal and flare response was used to compare quantitatively the antihistaminic potency of levocetirizine and desloratadine. In this double-blind, placebo-controlled crossover study, 24 healthy male non-atopic volunteers received weekly single doses of 1.25, 2.5 or 5 mg levocetirizine, 2.5, 5 or 10 mg desloratadine, or placebo. Four(More)
Argentophilic structures of Philophthalmus lucipetus miracidia and cercariae from Israel are described. Eighty-four of 87 miracidia examined displayed an epidermal plate arrangement of 6:8:4:2 = 20, similar to other Philophthalmus species. Twenty papilla-like structures are arranged on the terebratorium in 3 groups, along 1 axis. Sixteen body papillae are(More)
The exact assessment of nodal status in patients with rectal cancer is very important for the implement of adequate and motivated postopertaive therapeutic behavior. The relevance of the number of lymph nodes explored, the modern pathohistological techniques for detection of micrometastases and their importance for the prognosis, survival, and recurrence of(More)
The operative method of Pickrell for shaping a new anal sphincter from mm.graciles is described, emphasizing the refinements which the authors have introduced in it. In mobilizing the muscle, fascial fibers are left on both sides of the vascular-nervous bundle. They prevent the latter from overdistension when the muscle turns around the anal canal. Two(More)