Vivienne Mahon

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The OmpA outer membrane protein of Escherichia coli and other enterobacteria is a multifaceted protein. This protein is expressed to very high levels and ompA is tightly regulated at the posttranscriptional level. It can function as an adhesin and invasin, participate in biofilm formation, act as both an immune target and evasin, and serves as a receptor(More)
In most cases, Escherichia coli exists as a harmless commensal organism, but it may on occasion cause intestinal and/or extraintestinal disease. Enterotoxigenic E. coli (ETEC) is the predominant cause of E. coli-mediated diarrhea in the developing world and is responsible for a significant portion of pediatric deaths. In this study, we determined the(More)
The pathogenesis of diarrhoeal disease due to human enterotoxigenic Escherichia coli absolutely requires the expression of fimbriae. The expression of CS1 fimbriae is positively regulated by the AraC-like protein Rns. AraC-like proteins are DNA-binding proteins that typically contain two helix-turn-helix (HTH) motifs. A program of pentapeptide insertion(More)
Biofilm production by staphylococci is an important virulence determinant mediated by the icaADBC-encoded polysaccharide intercellular adhesin (PIA) or by surface and extracellular proteins. Deletion of the Staphylococcus accessory regulator sarX significantly reduced biofilm-forming capacity in Staphylococcus epidermidis CSF41498, whereas multicopy sarX(More)
INTRODUCTION Lymphocyte homeostasis is dependent on the γc cytokines. We hypothesised that sepsis in humans is associated with differential gene expression of the γc cytokines and their associated apoptosis mediators. METHODS The study population consisted of a total of 60 patients with severe sepsis, 15 with gram negative bacteraemia, 10 healthy controls(More)
Introduction: Lymphocyte homeostasis is dependent on the gc cytokines. We hypothesised that sepsis in humans is associated with differential gene expression of the gc cytokines and their associated apoptosis mediators. Methods: The study population consisted of a total of 60 patients with severe sepsis, 15 with gram negative bacteraemia, 10 healthy controls(More)
The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, 10 United Kingdom; Department of Veterinary Medicine, University of Cambridge, 11 Cambridge, United Kingdom; School of Chemistry and Molecular Biosciences, 12 University of Queensland, Brisbane, Australia; School of Immunity and Infection and 13 School of Biosciences, University of(More)
A Commensal Gone Bad: Complete Genome Sequence of the Prototypical Enterotoxigenic Escherichia coli Strain H10407vt Lisa C. Crossman/:!:§ Roy-R. Chaudhuri,2§ Scott A. Bcatson, Timothy J. Wclls, Mickacl Desvaux,11 Adam F. Cunningham, Nicola K. Petty, Vivienne Mahon, Carl Brinkley, Jon L. Hobman, Stephen J. Savarino, Susan M. Tumer, Mark J. Pallen, Charles W.(More)
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