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- Alan R. Champneys, Vivien Kirk, Edgar Knobloch, Bart E. Oldeman, James Sneyd
- SIAM J. Applied Dynamical Systems
- 2007

This paper considers a hierarchy of mathematical models of excitable media in one spatial dimension, specifically the FitzHugh-Nagumo equation and several models of the dynamics of intracellular calcium that have arisen in the work of Sneyd and collaborators. A common feature of the models is that they support solitary travelling pulse solutions which lie… (More)

- Xingjiang Chen, Karl Iremonger, Allan Herbison, Vivien Kirk, James Sneyd
- Bulletin of mathematical biology
- 2013

Gonadotropin-releasing hormone (GnRH) neurons are hypothalamic neurons that control the pulsatile release of GnRH that governs fertility and reproduction in mammals. The mechanisms underlying the pulsatile release of GnRH are not well understood. Some mathematical models have been developed previously to explain different aspects of these activities, such… (More)

- Emily Harvey, Vivien Kirk, Hinke M Osinga, James Sneyd, Martin Wechselberger
- Chaos
- 2010

In many cell types, oscillations in the concentration of free intracellular calcium ions are used to control a variety of cellular functions. It has been suggested [J. Sneyd et al., "A method for determining the dependence of calcium oscillations on inositol trisphosphate oscillations," Proc. Natl. Acad. Sci. U.S.A. 103, 1675-1680 (2006)] that the… (More)

- Elan Gin, Vivien Kirk, James Sneyd
- Journal of theoretical biology
- 2006

Many mathematical models of calcium oscillations model buffering implicitly by using a rapid buffering approximation. This approximation assumes that separate time scales can be distinguished, with the buffer reactions occurring on a faster time scale than the other calcium fluxes. The rapid buffering approximation is convenient as it reduces the model to a… (More)

- Alan R. Champneys, Vivien Kirk, Edgar Knobloch, Bart E. Oldeman, Jens D. M. Rademacher
- SIAM J. Applied Dynamical Systems
- 2009

The dynamics occurring near a heteroclinic cycle between a hyperbolic equilibrium and a hyperbolic periodic orbit is analyzed. The case of interest is when the equilibrium has a one-dimensional unstable manifold and a two-dimensional stable manifold while the stable and unstable manifolds of the periodic orbit are both two-dimensional. A codimension-two… (More)

- Emily P. Harvey, Vivien Kirk, Martin Wechselberger, James Sneyd
- J. Nonlinear Science
- 2011

We describe an example of a structurally stable heteroclinic network for which nearby orbits exhibit irregular but sustained switching between the various sub-cycles in the network. The mechanism for switching is the presence of spiralling due to complex eigenvalues in the flow linearised about one of the equilibria common to all cycles in the network. We… (More)

- Je-Chiang Tsai, Wenjun Zhang, Vivien Kirk, James Sneyd
- SIAM J. Applied Dynamical Systems
- 2012

The effect of small forced symmetry breaking on the dynamics near a structurally stable heteroclinic cycle connecting two equilibria and a periodic orbit is investigated. This type of system is known to exhibit complicated, possibly chaotic dynamics including irregular switching of sign of various phase space variables, but details of the mechanisms… (More)

- Pingyu Nan, Yangyang Wang, Vivien Kirk, Jonathan E. Rubin
- SIAM J. Applied Dynamical Systems
- 2015