Viviana Nilla Olavarria

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HAM/TSP is one of the most prevalent clinical manifestations of HTLV1 infection, likely related to high proviral load (PVL). We investigated HLA-A, -B and –C polymorphisms and determined the individual ancestry proportion of European, African and Amerindian in 209 HTLV-1 infected individuals in order to identify genetic factors that associate with HAM/TSP.(More)
Salvador-Bahia has the highest prevalence of HTLV-1 infection in Brazil; about 2% of the population is infected. In this city, the prevalence of HTLV in pregnant women is 1%. There is no data of the HTLV-1 prevalence in others cities of the Bahia's Recôncavo, where the population has similar social and demography characteristics to those from Salvador. Our(More)
A high human T-cell lymphotropic virus type 1 (HTLV-1) proviral load is described in HTLV-1-associated diseases, especially HAM/TSP. However, the cut-off value to define high levels of HTLV-1 proviral load is not well established. 281 HTLV-1-infected patients from the HTLV reference center in Salvador, Brazil, were followed from 2005 to 2008. Patients were(More)
Methods 281 HTLV-1-infected patients from the HTLV reference center in Salvador, Brazil, were followed from 2005 to 2008. Patients were classified as asymptomatic, possible, probableand definite-HAM/TSP, in accordance with diagnostic criteria proposed by De Castro-Costa et al 2006. HTLV-1proviral load was determined using realtime PCR. A receiver operator(More)
INTRODUCTION Females with systemic lupus erythematosus (SLE) have higher prevalence of human papillomavirus (HPV) infection, which can lead to the development of warts. Herein we report the first case of giant disseminated condylomatosis (GDC) in a SLE female on mycophenolate mofetil (MMF). CASE REPORT The patient, a 33-year-old, Black female, was(More)
BACKGROUND A high HTLV-1 proviral load is found in HTLV-1-associated diseases, mainly HAM/TSP. However, the association between proviral load and keratoconjunctivitis sicca (KCS) has not been well established. AIM To verify the association between KCS and HTLV-1 proviral load. STUDY DESIGN 104 HTLV-1 infected patients (51 asymptomatic and 52 with(More)
BACKGROUND High HTLV-1 proviral load (PVL) is mainly found in infected individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). However one third of asymptomatic carriers may have high PVL. This study aimed to evaluate the impact of PVL in the activation of T lymphocytes of asymptomatic individuals infected with HTLV-1. (More)
While most carriers of human T-cell leukemia virus type 1 (HTLV-1) remain asymptomatic throughout their lifetime, infection is associated with the development of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The exact parameters that determine these outcomes are unknown but are believed to include host(More)
Advanced Laboratory of Public Health, Gonç alo Moniz Center, Fundaç ão Oswaldo Cruz, Salvador, Bahia, Brazil Bahiana School of Medicine and Public Health (EBMSP), Salvador, Bahia, Brazil Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan Viral Immunology Section, NINDS/NIH,(More)
The diagnosis of HAM/TSP is based on criteria, as proposed by the World Health Organization, revised in 1989. This primarily relies on diagnosis through laboratory criteria and an extensive list of neurological signs and symptoms. Consequentially HAM/TSP diagnosis is often delayed or not confirmed, especially in countries with limited resources. There is(More)