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Protein kinases control cellular decision processes by phosphorylating specific substrates. Thousands of in vivo phosphorylation sites have been identified, mostly by proteome-wide mapping. However, systematically matching these sites to specific kinases is presently infeasible, due to limited specificity of consensus motifs, and the influence of contextual(More)
Over 40 missense mutations in the human SCN1A sodium channel gene are linked to an epilepsy syndrome termed genetic epilepsy with febrile seizures plus (GEFS+). Inheritance of GEFS+ is dominant, but the underlying cellular mechanisms remain poorly understood. Here we report that knock-in of a GEFS+ SCN1A mutation (K1270T) into the Drosophila sodium channel(More)
In 2007, Vietnam experienced swine disease outbreaks causing clinical signs similar to the 'porcine high fever disease' that occurred in China during 2006. Analysis of diagnostic samples from the disease outbreaks in Vietnam identified porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV-2). Additionally,(More)
The mitogenic and second-messenger signals that promote cell proliferation often proceed through multienzyme complexes. The kinase-anchoring protein Gravin integrates cAMP and calcium/phospholipid signals at the plasma membrane by sequestering protein kinases A and C with G protein-coupled receptors. In this report we define a role for Gravin as a temporal(More)
Bruton's tyrosine kinase (Btk), belonging to the Tec family of tyrosine kinases (TFKs), is essential for B-lymphocyte development. Abrogation of Btk signaling causes human X-linked agammaglobulinemia (XLA) and murine X-linked immunodeficiency (Xid). We employed affinity purification of Flag-tagged Btk, combined with tandem mass spectrometry, to capture and(More)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an endogenous secreted peptide and, in preclinical studies, preferentially induces apoptosis in tumor cells rather than in normal cells. The acquisition of resistance in cells exposed to TRAIL or its mimics limits their clinical efficacy. Because kinases are intimately involved in the(More)
The research programme which underlies this paper focuses on understanding the process of addressing " creative " or ill-structured problems – an economically significant process and one which pervades the professional lives of teams of professionals such as software engineers, managers and strategic planners. This class of problem is poorly understood and,(More)
Naomi began working at the Icahn School of Medicine at Mount Sinai after graduating with general honors from Vassar College, where she majored in Mathematics. She joined the Department of Geriatrics and Palliative Medicine in 2012 as a grants manager, where she has continued throughout her graduate education. In 2015, Naomi joined the first cohort of the(More)
A significant body of research exists that describes many well known dimensions of " same or different " " time or place " group activities including the effects of group size, group performance, computer support, communication media and many others. This research investigates ICT-mediated support approaches for domain-agnostic, group work processes in "(More)
Over 40 missense mutations in the human SCN1A sodium channel gene are linked to an epilepsy syndrome termed genetic epilepsy with febrile seizures plus (GEFSϩ). Inheritance of GEFSϩ is dominant, but the underlying cellular mechanisms remain poorly understood. Here we report that knock-in of a GEFSϩ SCN1A mutation (K1270T) into the Drosophila sodium channel(More)