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The Gene Ontology Annotation (GOA) database (http://www.ebi.ac.uk/GOA) aims to provide high-quality electronic and manual annotations to the UniProt Knowledgebase (Swiss-Prot, TrEMBL and PIR-PSD) using the standardized vocabulary of the Gene Ontology (GO). As a supplementary archive of GO annotation, GOA promotes a high level of integration of the knowledge(More)
The Gene Regulation Ontology (GRO) is designed as a novel approach to model complex events that are part of the gene regulatory processes. We introduce the design requirements for such a conceptual model and discuss terminological resources suitable to base its construction on. The ontology defines gene regulation events in terms of ontological classes and(More)
As developers and primary users of MTI and MetaMap Névéol et al. made a number of interesting comments on our recent publication in Bioinformatics. However, some of the results and conclusions found in the reply seem premature and lack proper clarification. In response to the methodological considerations, we emphasize that in our paper we compare different(More)