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Association of exercise with quality of life and mood symptoms in a comparative effectiveness study of bipolar disorder.
TLDR
There appears to be a mood-specific relationship between exercise frequency and polarity such that depression is associated with less exercise and mania with more exercise in individuals with bipolar disorder. Expand
Medical burden in bipolar disorder: findings from the Clinical and Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder study (Bipolar CHOICE).
TLDR
There appears to be a substantial medical burden associated with bipolar disorder, highlighting the need for collaborative care among psychiatric and general medical providers to address both psychiatric and other medical needs concomitantly in this group of patients. Expand
Anticonvulsants in bipolar disorder.
TLDR
Results from a large study indicate that LAM has significant efficacy in bipolar depression without the associated risks of cycle acceleration or manic/hypomanic switches, and should be considered along with lithium or DIV as treatment of choice in the long-term management of bipolar disorder. Expand
Treatment characteristics and illness burden among European Americans, African Americans, and Latinos in the first 2,000 patients of the systematic treatment enhancement program for bipolar disorder.
TLDR
Despite treatment differences and greater comorbidity and sympomatology, there were no differences among the three groups in overall functioning, suggesting additional outcome measurement is warranted. Expand
Bipolar mixed features - Results from the comparative effectiveness for bipolar disorder (Bipolar CHOICE) study.
TLDR
The DSM-5 narrower, non-overlapping definition of mixed episodes resulted in fewer patients who met mixed criteria compared to DSM-IV, andSymptom severity was associated with increased mixed features with a high rate of mixed features in patients with mania/hypomania. Expand
Bipolar CHOICE (Clinical Health Outcomes Initiative in Comparative Effectiveness): a pragmatic 6-month trial of lithium versus quetiapine for bipolar disorder.
TLDR
Despite adequate power to detect clinically meaningful differences, outcomes with lithium + APT and quetiapine +APT were not significantly different across 6 months of treatment for bipolar disorder. Expand
Development of the Bipolar Inventory of Symptoms Scale: concurrent validity, discriminant validity and retest reliability
TLDR
The BISS is a reliable and valid instrument broadly applicable in clinical research to assess the comprehensive domains of bipolar disorder and relationship to a measure of overall function for a new psychometric rating instrument is reported. Expand
Effect of adjunctive benzodiazepines on clinical outcomes in lithium- or quetiapine-treated outpatients with bipolar I or II disorder: results from the Bipolar CHOICE trial.
TLDR
Adjunctive benzodiazepines may not significantly affect clinical outcome in lithium- or quetiapine-treated patients with bipolar I or II disorder over 6 months, after controlling for potential confounding factors. Expand
Psychotherapy use in bipolar disorder: Association with functioning and illness severity
TLDR
The data suggest that a minority of individuals with bipolar disorder attend psychotherapy services, and those that do have greater illness burden are more likely to have moderate to high suicide risk and at least one anxiety disorder. Expand
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