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In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) functions to restrict cells from entering S phase by binding and sequestering E2f activators (E2f1, E2f2 and E2f3), which are invariably portrayed as the ultimate effectors of a transcriptional program that commit cells to enter and progress through S phase. Using a(More)
—Increasingly, SE researchers use search-based optimization techniques to solve SE problems with multiple conflicting objectives. These techniques often apply CPU-intensive evolutionary algorithms to explore generations of mutations to a population of candidate solutions. An alternative approach, proposed in this paper, is to start with a very large(More)
Context: One of the black arts of data mining is learning the magic parameters that control the learners. In software analytics, at least for defect prediction, several methods, like grid search and differential evolution(DE), have been proposed to learn those parameters. They've been proved to be able to improve learner performance. Objective: We want to(More)
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