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BACKGROUND The risk for colorectal cancer (CRC) in ulcerative colitis (UC) in India is not known. METHOD Retrospective cohort from a tertiary level hospital in South India. Analysis of archived records of all patients with UC who underwent colonoscopy and segmental biopsies over the last 25 years. Incidence densities and risk of developing high grade(More)
Chronic inflammation is a driving force for gastric carcinogenesis. Reactive oxygen species (ROS) generated during the inflammatory process generates DNA damage that is processed through the DNA repair pathways. In this study, we profiled key DNA repair proteins (single-strand-selective monofunctional uracil-DNA glycosylase 1 [SMUG1], Flap endonuclease 1(More)
Medial-wall perforation secondary to pelvic osteolysis impacts planning of acetabular revision surgery and may result in pelvic fracture. We compared commonly used radiographic signs for detecting medial-wall perforation (ballooning or discontinuity of Kohler's line or the iliopubic line) to findings from computed tomography (CT) in 27 cementless total hip(More)
BACKGROUND AND PURPOSE With younger patients seeking reconstructions and the activity-based demands placed on the arthroplasty construct, consideration of the role that implant characteristics play in arthroplasty longevity is warranted. We therefore evaluated the risk of early revision for a monoblock all-polyethylene tibial component compared to a(More)
This study retrospectively evaluated the clinical outcome of primary total hip arthroplasty as a function of stem diameter in 1545 patients implanted with extensively porous-coated stems. Less than 2% of femoral components were loose or revised; femoral survivorship was 97.9% at 15 years. Of patients with stable components, 95 to 97% had increased function,(More)
INTRODUCTION Ataxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is a key sensor of single-stranded DNA associated with stalled replication forks and repair intermediates generated during DNA repair. XRCC1 is a critical enzyme in single strand break repair and base excision repair. XRCC1-LIG3 complex is also an important contributor to the(More)
Because surgeons are electing to perform simultaneous bilateral total knee arthroplasty (TKA), it is important to identify which patients are at increased risk. We performed a retrospective cohort analysis of 150 patients with unilateral TKA vs 150 patients with simultaneous bilateral TKA. The bilateral group demonstrated a 2.1 times greater mean overall(More)
FEN1 has key roles in Okazaki fragment maturation during replication, long patch base excision repair, rescue of stalled replication forks, maintenance of telomere stability and apoptosis. FEN1 may be dysregulated in breast and ovarian cancers and have clinicopathological significance in patients. We comprehensively investigated FEN1 mRNA expression in(More)
BACKGROUND Reduction of gross diarrhea rate in excess of that seen over time with intravenous therapy and appropriate antibiotics is not usually achieved by oral glucose-electrolyte rehydration therapy for cholera and cholera-like diarrheas. METHODOLOGY AND PRINCIPAL FINDINGS This prospective randomized clinical trial at a tertiary referral hospital in(More)
BACKGROUND CONTEXT Minimal access surgery is becoming more popular for spinal fusion because of a lower theoretical risk of complications and shorter postoperative recovery period, compared with the traditional open approach. The lateral approach uses retroperitoneal transpsoas access to the vertebra, obviating the need for an approach surgeon and(More)