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Multi-walled carbon nanotubes induce oxidative stress and apoptosis in human lung cancer cell line-A549
TLDR
Results indicate the involvement of oxidative stress and apoptosis in A549 cells exposed to MWCNTs and provide insights of the mechanisms involved in M WCNTs-induced apoptosis at cellular level.
Differential responses of Trans-Resveratrol on proliferation of neural progenitor cells and aged rat hippocampal neurogenesis
TLDR
It is successfully demonstrated that Resveratrol exhibits dose dependent discrepancies and at a lower concentration can have a positive impact on the proliferation, survival of NPCs and aged rat hippocampal neurogenesis implicating its potential as a candidate for restorative therapies against age related disorders.
Monocrotophos Induces the Expression and Activity of Xenobiotic Metabolizing Enzymes in Pre-Sensitized Cultured Human Brain Cells
TLDR
The data provide better understanding of the metabolizing capability of the human brain cells against xenobiotics and suggest the xenobiotic metabolizing capabilities of these cells against MCP are likely to be involved in protecting the neurons from environmental insults and safeguard them from toxicity.
Emerging targets for diabetes
TLDR
This review focuses on PTP-1B and GSK-3 inhibitors studied until now, which have emerged as validated targets for treating type 2 diabetes.
CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination
TLDR
It is shown that the elevated and persistent levels of p53 displayed by CS cells are due to the insufficient ubiquitination of the p53 protein, and it is demonstrated that CSA and CSB proteins associate in a unique complex with p53 and Mdm2; this interaction greatly stimulates the ubiquitinated p53 in an MDM2-dependent manner.
Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment.
TLDR
Findings support the D3R as a target for opioid dependence treatment and compound 19 as a new lead molecule for development.
Hamster Sperm Capacitation: Role of Pyruvate Dehydrogenase A and Dihydrolipoamide Dehydrogenase1
TLDR
It is established that PDHA is required for hamster sperm hyperactivation and acrosome reaction, and DLD is required in the presence of BP and MICA, and ROS, cAMP, and calcium are involved downstream to PDHA.
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