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The present paper extends the literature investigating key drivers leading certain patents to exert a stronger influence on the subsequent technological developments (inventions) than other ones. We investigated six key determinants, as (i) the use of scientific knowledge, (ii) the breadth of the technological base, (iii) the existence of collaboration in(More)
Purpose – The purpose of this paper is to analyse if and how technology districts use proximity dimensions (such as geographical, organizational, and cognitive) as a communication resource for accessing external knowledge sources. Design/methodology/approach – To achieve this purpose, the organizational and cognitive links between technology districts’(More)
US input-output tables are of the type where intermediate inputs record the sum of imported and domestically produced goods. In modeling exercises this implies that imports are required to be specified exogenously. This has two consequences, which seriously restricts the usefulness of US-type tables. First, the multipliers can only be interpreted under the(More)
BACKGROUND Preoperative treatment of resectable liver metastases from colorectal cancer (CRC) is a matter of debate. The aim of this study was to assess the feasibility and activity of bevacizumab plus FOLFIRI in this setting. METHODS Patients aged 18-75 years, PS 0-1, with resectable liver-confined metastases from CRC were eligible. They received(More)
Locally advanced rectal cancer carries out a dismail prognosis despite optimal surgery in terms of local and distant relapses. Neoadjuvant chemoradiation offers good results with tumor downstaging and downsizing and leads to more radical surgery with conservative intent. Selection of patients and an intensive chemotherapy may improve long term results. Our(More)